Stimuli‐activatable nanomedicines for chemodynamic therapy of cancer

Chemodynamic therapy (CDT) takes the advantages of Fenton‐type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the hig...

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Published in:	Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Vol. 12; no. 4; pp. e1614 - n/a
Main Authors:	Wang, Weiqi, Jin, Yilan, Xu, Zhiai, Liu, Xiao, Bajwa, Sadia Z., Khan, Waheed S., Yu, Haijun
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01-07-2020 Wiley Subscription Services, Inc
Subjects:	Cancer cancer nanomedicine Chemical energy Chemical reactions chemodynamic therapy Cytotoxicity Fenton reaction Free radicals Hydrogen peroxide Hydroxyl radicals Invasiveness Nanomaterials Nanotechnology Reactive oxygen species Stimuli stimuli responsive tumor microenvironment Tumors cancer nanomedicine Fenton reaction tumor microenvironment stimuli responsive chemodynamic therapy
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Abstract	Chemodynamic therapy (CDT) takes the advantages of Fenton‐type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable reactive oxygen species generation exhibits preferable therapeutic performance and satisfying biosafety. In this review article, we summarized the recent advances of stimuli‐activatable nanomedicines for CDT. We also overviewed the strategies for augmenting CDT performance, including increasing the catalytic efficacy through rational design of the nanomaterials, modulating the reaction condition, inputting external energy field, and regulating the tumor microenvironment. Furthermore, we discussed the potential and challenges of stimuli‐activatable nanomedicine for clinical translation and future development of CDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Schematic illustration of activatable nanomedicine for chemodynamic therapy (CDT). The ˙OH produced by intratumoral Fenton or Fenton‐like reactions could kill cancer cells effectively. CDT shows its own merits for cancer treatment, including highly specific toward the TME, highly toxicity ˙OH production, and reverse the hypoxia and immunosuppressive TME.
AbstractList	Chemodynamic therapy (CDT) takes the advantages of Fenton‐type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable reactive oxygen species generation exhibits preferable therapeutic performance and satisfying biosafety. In this review article, we summarized the recent advances of stimuli‐activatable nanomedicines for CDT. We also overviewed the strategies for augmenting CDT performance, including increasing the catalytic efficacy through rational design of the nanomaterials, modulating the reaction condition, inputting external energy field, and regulating the tumor microenvironment. Furthermore, we discussed the potential and challenges of stimuli‐activatable nanomedicine for clinical translation and future development of CDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Schematic illustration of activatable nanomedicine for chemodynamic therapy (CDT). The ˙OH produced by intratumoral Fenton or Fenton‐like reactions could kill cancer cells effectively. CDT shows its own merits for cancer treatment, including highly specific toward the TME, highly toxicity ˙OH production, and reverse the hypoxia and immunosuppressive TME. Chemodynamic therapy (CDT) takes the advantages of Fenton‐type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable reactive oxygen species generation exhibits preferable therapeutic performance and satisfying biosafety. In this review article, we summarized the recent advances of stimuli‐activatable nanomedicines for CDT. We also overviewed the strategies for augmenting CDT performance, including increasing the catalytic efficacy through rational design of the nanomaterials, modulating the reaction condition, inputting external energy field, and regulating the tumor microenvironment. Furthermore, we discussed the potential and challenges of stimuli‐activatable nanomedicine for clinical translation and future development of CDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Chemodynamic therapy (CDT) takes the advantages of Fenton-type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable reactive oxygen species generation exhibits preferable therapeutic performance and satisfying biosafety. In this review article, we summarized the recent advances of stimuli-activatable nanomedicines for CDT. We also overviewed the strategies for augmenting CDT performance, including increasing the catalytic efficacy through rational design of the nanomaterials, modulating the reaction condition, inputting external energy field, and regulating the tumor microenvironment. Furthermore, we discussed the potential and challenges of stimuli-activatable nanomedicine for clinical translation and future development of CDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging. Chemodynamic therapy (CDT) takes the advantages of Fenton‐type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable reactive oxygen species generation exhibits preferable therapeutic performance and satisfying biosafety. In this review article, we summarized the recent advances of stimuli‐activatable nanomedicines for CDT. We also overviewed the strategies for augmenting CDT performance, including increasing the catalytic efficacy through rational design of the nanomaterials, modulating the reaction condition, inputting external energy field, and regulating the tumor microenvironment. Furthermore, we discussed the potential and challenges of stimuli‐activatable nanomedicine for clinical translation and future development of CDT.This article is categorized under:Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic DiseaseNanotechnology Approaches to Biology > Nanoscale Systems in BiologyDiagnostic Tools > In Vivo Nanodiagnostics and Imaging
Author	Xu, Zhiai Jin, Yilan Bajwa, Sadia Z. Wang, Weiqi Liu, Xiao Khan, Waheed S. Yu, Haijun
Author_xml	– sequence: 1 givenname: Weiqi orcidid: 0000-0002-3296-7078 surname: Wang fullname: Wang, Weiqi organization: Shanghai Institute of Materia Medica, Chinese Academy of Sciences – sequence: 2 givenname: Yilan surname: Jin fullname: Jin, Yilan organization: Shanghai Institute of Materia Medica, Chinese Academy of Sciences – sequence: 3 givenname: Zhiai surname: Xu fullname: Xu, Zhiai organization: East China Normal University – sequence: 4 givenname: Xiao surname: Liu fullname: Liu, Xiao organization: Nantong University – sequence: 5 givenname: Sadia Z. surname: Bajwa fullname: Bajwa, Sadia Z. organization: National Institute for Biotechnology and Genetic Engineering (NIBGE) – sequence: 6 givenname: Waheed S. surname: Khan fullname: Khan, Waheed S. organization: National Institute for Biotechnology and Genetic Engineering (NIBGE) – sequence: 7 givenname: Haijun orcidid: 0000-0002-3398-0880 surname: Yu fullname: Yu, Haijun email: hjyu@simm.ac.cn organization: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Snippet	Chemodynamic therapy (CDT) takes the advantages of Fenton‐type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl... Chemodynamic therapy (CDT) takes the advantages of Fenton-type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl...
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StartPage	e1614
SubjectTerms	Cancer cancer nanomedicine Chemical energy Chemical reactions chemodynamic therapy Cytotoxicity Fenton reaction Free radicals Hydrogen peroxide Hydroxyl radicals Invasiveness Nanomaterials Nanotechnology Reactive oxygen species Stimuli stimuli responsive tumor microenvironment Tumors
Title	Stimuli‐activatable nanomedicines for chemodynamic therapy of cancer
URI	https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fwnan.1614 https://www.ncbi.nlm.nih.gov/pubmed/32011108 https://www.proquest.com/docview/2409636418 https://search.proquest.com/docview/2350338931
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