Stimuli‐activatable nanomedicines for chemodynamic therapy of cancer

• Published in: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Vol. 12; no. 4; pp. e1614 - n/a
• Main Authors: Wang, Weiqi, Jin, Yilan, Xu, Zhiai, Liu, Xiao, Bajwa, Sadia Z., Khan, Waheed S., Yu, Haijun
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01-07-2020; Wiley Subscription Services, Inc
• Subjects: Cancer; cancer nanomedicine; Chemical energy; Chemical reactions; chemodynamic therapy; Cytotoxicity; Fenton reaction; Free radicals; Hydrogen peroxide; Hydroxyl radicals; Invasiveness; Nanomaterials; Nanotechnology; Reactive oxygen species; Stimuli; stimuli responsive; tumor microenvironment; Tumors; cancer nanomedicine; Fenton reaction; tumor microenvironment; stimuli responsive; chemodynamic therapy
• ISSN: 1939-5116; 1939-0041
• DOI: 10.1002/wnan.1614

Chemodynamic therapy (CDT) takes the advantages of Fenton‐type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable reactive oxygen species generation exhibits preferable therapeutic performance and satisfying biosafety. In this review article, we summarized the recent advances of stimuli‐activatable nanomedicines for CDT. We also overviewed the strategies for augmenting CDT performance, including increasing the catalytic efficacy through rational design of the nanomaterials, modulating the reaction condition, inputting external energy field, and regulating the tumor microenvironment. Furthermore, we discussed the potential and challenges of stimuli‐activatable nanomedicine for clinical translation and future development of CDT.
This article is categorized under:
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Schematic illustration of activatable nanomedicine for chemodynamic therapy (CDT). The ˙OH produced by intratumoral Fenton or Fenton‐like reactions could kill cancer cells effectively. CDT shows its own merits for cancer treatment, including highly specific toward the TME, highly toxicity ˙OH production, and reverse the hypoxia and immunosuppressive TME.