Effect of Nellore (Bos indicus) donor age on in‐vitro embryo production and pregnancy rate

The aim of this study was to evaluate the effect of age of Nellore (Bos indicus) donors on the efficiency of in vitro embryo production (IVEP) and pregnancy rate. Thirty‐six donors, including 11 female calves (13 ± 0.61 months), 17 prepubertal heifers (25 ± 0.78 months) and 8 cows (83 ± 28 months),...

Full description

Saved in:

Bibliographic Details
Published in:	Reproduction in domestic animals Vol. 57; no. 9; pp. 980 - 988
Main Authors:	Silva, Marina Oliveira, Borges, Marcelo Sant'Ana, Fernandes, Luana Gomes, Rodrigues, Naiara Nantes, Watanabe, Yeda Fumie, Joaquim, Daniel Carlino, Oliveira, Clara Slade, Feuchard, Viviane Luzia Silva, Cyrillo, Joslaine Noely Santos Gonçalves, Mercadante, Maria Eugênia Zerlotti, Monteiro, Fabio Morato
Format:	Journal Article
Language:	English
Published:	Germany Blackwell Publishing Ltd 01-09-2022
Subjects:	Age Age factors Blastocysts Bos taurus indicus Calves Caspase caspase‐3 Cattle embryo quality Embryos Estrus cycle Females Follicles Gametocytes IGFBP 2 Insulin-like growth factor-binding protein 2 IVEP oocyte quality Oocytes Pregnancy IGFBP 2 embryo quality IVEP oocyte quality caspase-3
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	The aim of this study was to evaluate the effect of age of Nellore (Bos indicus) donors on the efficiency of in vitro embryo production (IVEP) and pregnancy rate. Thirty‐six donors, including 11 female calves (13 ± 0.61 months), 17 prepubertal heifers (25 ± 0.78 months) and 8 cows (83 ± 28 months), were submitted to 3 procedures of ovum pickup (OPU) on random days of the estrous cycle at intervals of 21 days. Caspase‐3 and IGFBP2 were quantified in oocytes and blastocysts for the evaluation of oocyte and embryo quality. The produced embryos were vitrified (n = 445) and transferred to synchronized recipients. Cows produced a larger number of follicles (cows: 54.5 ± 6.2; calves: 20.0 ± 0.57; prepubertal heifers: 20.8 ± 0.46), total oocytes (cows: 45.97 ± 7.22; calves: 28.93 ± 6.14; prepubertal heifers: 27.21 ± 4.94) and cleaved oocytes (cows: 21.14 ± 4.22; calves: 13.09 ± 3.72; prepubertal heifers: 12.4 ± 3.19). The cleavage rate was similar between age categories; however, cows tended (p < 0.07) to produce a larger number of blastocysts (9.74 ± 2.26) per OPU than calves (5.57 ± 1.99) and prepubertal heifers tended to have a higher blastocyst yield (35.4%) than calves (27.1%) (p < .07). The expression levels of IGFBP2 and caspase‐3 were higher in oocytes derived from calves compared to the other two categories. The pregnancy rate was higher in calves (43.1%) and cows (40.4%) than in prepubertal heifers (33.8%) (p = .03). Despite the larger numbers of follicles and viable oocytes in cows, the blastocyst production results and pregnancy rates obtained indicate that the use of young females as oocyte donors in IVEP is feasible and may contribute to reduce the generation interval.
AbstractList	The aim of this study was to evaluate the effect of age of Nellore (Bos indicus) donors on the efficiency of in vitro embryo production (IVEP) and pregnancy rate. Thirty‐six donors, including 11 female calves (13 ± 0.61 months), 17 prepubertal heifers (25 ± 0.78 months) and 8 cows (83 ± 28 months), were submitted to 3 procedures of ovum pickup (OPU) on random days of the estrous cycle at intervals of 21 days. Caspase‐3 and IGFBP2 were quantified in oocytes and blastocysts for the evaluation of oocyte and embryo quality. The produced embryos were vitrified (n = 445) and transferred to synchronized recipients. Cows produced a larger number of follicles (cows: 54.5 ± 6.2; calves: 20.0 ± 0.57; prepubertal heifers: 20.8 ± 0.46), total oocytes (cows: 45.97 ± 7.22; calves: 28.93 ± 6.14; prepubertal heifers: 27.21 ± 4.94) and cleaved oocytes (cows: 21.14 ± 4.22; calves: 13.09 ± 3.72; prepubertal heifers: 12.4 ± 3.19). The cleavage rate was similar between age categories; however, cows tended (p < 0.07) to produce a larger number of blastocysts (9.74 ± 2.26) per OPU than calves (5.57 ± 1.99) and prepubertal heifers tended to have a higher blastocyst yield (35.4%) than calves (27.1%) (p < .07). The expression levels of IGFBP2 and caspase‐3 were higher in oocytes derived from calves compared to the other two categories. The pregnancy rate was higher in calves (43.1%) and cows (40.4%) than in prepubertal heifers (33.8%) (p = .03). Despite the larger numbers of follicles and viable oocytes in cows, the blastocyst production results and pregnancy rates obtained indicate that the use of young females as oocyte donors in IVEP is feasible and may contribute to reduce the generation interval. The aim of this study was to evaluate the effect of age of Nellore (Bos indicus) donors on the efficiency of in vitro embryo production (IVEP) and pregnancy rate. Thirty‐six donors, including 11 female calves (13 ± 0.61 months), 17 prepubertal heifers (25 ± 0.78 months) and 8 cows (83 ± 28 months), were submitted to 3 procedures of ovum pickup (OPU) on random days of the estrous cycle at intervals of 21 days. Caspase‐3 and IGFBP2 were quantified in oocytes and blastocysts for the evaluation of oocyte and embryo quality. The produced embryos were vitrified (n = 445) and transferred to synchronized recipients. Cows produced a larger number of follicles (cows: 54.5 ± 6.2; calves: 20.0 ± 0.57; prepubertal heifers: 20.8 ± 0.46), total oocytes (cows: 45.97 ± 7.22; calves: 28.93 ± 6.14; prepubertal heifers: 27.21 ± 4.94) and cleaved oocytes (cows: 21.14 ± 4.22; calves: 13.09 ± 3.72; prepubertal heifers: 12.4 ± 3.19). The cleavage rate was similar between age categories; however, cows tended (p < 0.07) to produce a larger number of blastocysts (9.74 ± 2.26) per OPU than calves (5.57 ± 1.99) and prepubertal heifers tended to have a higher blastocyst yield (35.4%) than calves (27.1%) ( p < .07). The expression levels of IGFBP2 and caspase‐3 were higher in oocytes derived from calves compared to the other two categories. The pregnancy rate was higher in calves (43.1%) and cows (40.4%) than in prepubertal heifers (33.8%) ( p = .03). Despite the larger numbers of follicles and viable oocytes in cows, the blastocyst production results and pregnancy rates obtained indicate that the use of young females as oocyte donors in IVEP is feasible and may contribute to reduce the generation interval. The aim of this study was to evaluate the effect of age of Nellore (Bos indicus) donors on the efficiency of in vitro embryo production (IVEP) and pregnancy rate. Thirty-six donors, including 11 female calves (13±0.61 months), 17 prepubertal heifers (25±0.78 months) and 8 cows (83±28 months), were submitted to 3 procedures of ovum pick up (OPU) on random days of the estrous cycle at intervals of 21 days. Caspase-3 and IGFBP2 were quantified in oocytes and blastocysts for the evaluation of oocyte and embryo quality. The produced embryos were vitrified (n=445) and transferred to synchronized recipients. Cows produced a larger number of follicles (cows: 54.5±6.2; calves: 20.0±0.57; prepubertal heifers: 20.8±0.46), total oocytes (cows: 45.97±7.22; calves: 28.93±6.14; prepubertal heifers: 27.21±4.94), and cleaved oocytes (cows: 21.14±4.22; calves: 13.09±3.72; prepubertal heifers: 12.4±3.19). The cleavage rate was similar between age categories; however, cows tended (p<0.07) to produce a larger number of blastocysts (9.74±2.26) per OPU than calves (5.57±1.99) and prepubertal heifers tended to have a higher blastocyst yield (35.4%) than calves (27.1%) (p<0.07). The expression levels of IGFBP2 and caspase-3 were higher in oocytes derived from calves compared to the other two categories. The pregnancy rate was higher in calves (43.1%) and cows (40.4%) than in prepubertal heifers (33.8%) (p=0.03). Despite the larger numbers of follicles and viable oocytes in cows, the blastocyst production results and pregnancy rates obtained indicate that the use of young females as oocyte donors in IVEP is feasible and may contribute to reduce the generation interval. The aim of this study was to evaluate the effect of age of Nellore (Bos indicus) donors on the efficiency of in vitro embryo production (IVEP) and pregnancy rate. Thirty‐six donors, including 11 female calves (13 ± 0.61 months), 17 prepubertal heifers (25 ± 0.78 months) and 8 cows (83 ± 28 months), were submitted to 3 procedures of ovum pickup (OPU) on random days of the estrous cycle at intervals of 21 days. Caspase‐3 and IGFBP2 were quantified in oocytes and blastocysts for the evaluation of oocyte and embryo quality. The produced embryos were vitrified (n = 445) and transferred to synchronized recipients. Cows produced a larger number of follicles (cows: 54.5 ± 6.2; calves: 20.0 ± 0.57; prepubertal heifers: 20.8 ± 0.46), total oocytes (cows: 45.97 ± 7.22; calves: 28.93 ± 6.14; prepubertal heifers: 27.21 ± 4.94) and cleaved oocytes (cows: 21.14 ± 4.22; calves: 13.09 ± 3.72; prepubertal heifers: 12.4 ± 3.19). The cleavage rate was similar between age categories; however, cows tended (p < 0.07) to produce a larger number of blastocysts (9.74 ± 2.26) per OPU than calves (5.57 ± 1.99) and prepubertal heifers tended to have a higher blastocyst yield (35.4%) than calves (27.1%) (p < .07). The expression levels of IGFBP2 and caspase‐3 were higher in oocytes derived from calves compared to the other two categories. The pregnancy rate was higher in calves (43.1%) and cows (40.4%) than in prepubertal heifers (33.8%) (p = .03). Despite the larger numbers of follicles and viable oocytes in cows, the blastocyst production results and pregnancy rates obtained indicate that the use of young females as oocyte donors in IVEP is feasible and may contribute to reduce the generation interval.
Author	Watanabe, Yeda Fumie Mercadante, Maria Eugênia Zerlotti Silva, Marina Oliveira Fernandes, Luana Gomes Borges, Marcelo Sant'Ana Joaquim, Daniel Carlino Cyrillo, Joslaine Noely Santos Gonçalves Feuchard, Viviane Luzia Silva Rodrigues, Naiara Nantes Oliveira, Clara Slade Monteiro, Fabio Morato
Author_xml	– sequence: 1 givenname: Marina Oliveira surname: Silva fullname: Silva, Marina Oliveira organization: Beef Cattle Research Center – sequence: 2 givenname: Marcelo Sant'Ana orcidid: 0000-0002-8842-5710 surname: Borges fullname: Borges, Marcelo Sant'Ana organization: Beef Cattle Research Center – sequence: 3 givenname: Luana Gomes surname: Fernandes fullname: Fernandes, Luana Gomes organization: São Paulo State University (UNESP) – sequence: 4 givenname: Naiara Nantes orcidid: 0000-0001-5580-9606 surname: Rodrigues fullname: Rodrigues, Naiara Nantes organization: São Paulo State University (UNESP) – sequence: 5 givenname: Yeda Fumie surname: Watanabe fullname: Watanabe, Yeda Fumie organization: Vitrogen‐WTAvet – sequence: 6 givenname: Daniel Carlino surname: Joaquim fullname: Joaquim, Daniel Carlino organization: Vitrogen‐WTAvet – sequence: 7 givenname: Clara Slade orcidid: 0000-0002-8599-0685 surname: Oliveira fullname: Oliveira, Clara Slade organization: Embrapa Dairy Cattle, Gado de Leite – sequence: 8 givenname: Viviane Luzia Silva surname: Feuchard fullname: Feuchard, Viviane Luzia Silva organization: Embrapa Dairy Cattle, Gado de Leite – sequence: 9 givenname: Joslaine Noely Santos Gonçalves surname: Cyrillo fullname: Cyrillo, Joslaine Noely Santos Gonçalves organization: Beef Cattle Research Center – sequence: 10 givenname: Maria Eugênia Zerlotti surname: Mercadante fullname: Mercadante, Maria Eugênia Zerlotti organization: Beef Cattle Research Center – sequence: 11 givenname: Fabio Morato orcidid: 0000-0003-4344-4667 surname: Monteiro fullname: Monteiro, Fabio Morato email: fabiomoratomonteiro@yahoo.com.br organization: São Paulo State University (UNESP)
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/35612981$$D View this record in MEDLINE/PubMed
BookMark	eNp1kMtqVTEUhoNU7Gl14AtIwEk72G3ul2FbWxWKguhMCNnJStnlnKQmeytn5iP0GX0So6c6EMwkZK2Pnz_fAdrLJQNCzyk5of2c1uhPqKBKPEIrKrgdiOR0D62I5WpQWpl9dNDaLSFUGq2foH0uFWXW0BX6fJkShBmXhN_Bel0q4KPz0vCU4xSWdoxjyaVifwO45D798f3-6zTXgmEz1m3Bd7XEJcxTX_oc-xNuss9hi6uf4Sl6nPy6wbOH-xB9urr8ePFmuH7_-u3F2fUQuORiSEYTRbQWLFjLkvEhGMsZU0wQb701PgITo9aBiQRERRgtE2FMUvPobeSH6GiX29t8WaDNbjO10L_jM5SlOaaUlYQaKTv68h_0tiw193aO6e5SKiNop453VKiltQrJ3dVp4-vWUeJ-KXddufutvLMvHhKXcQPxL_nHcQdOd8C3aQ3b_ye5D6_OdpE_AW4Bi_U
CitedBy_id	crossref_primary_10_2478_aoas_2023_0029 crossref_primary_10_1590_1984_3143_ar2022_0108 crossref_primary_10_1016_j_theriogenology_2024_03_012 crossref_primary_10_1080_10495398_2023_2279612
Cites_doi	10.1095/biolreprod.108.071670 10.1016/j.theriogenology.2016.04.064 10.1262/jrd.17014 10.1530/jrf.0.1000027 10.1095/biolreprod.104.032102 10.1590/S1516-35982003000100014 10.1038/sj.cdd.4400439 10.1016/j.cvfa.2016.01.008 10.1530/rep.0.1230789 10.1111/j.1365-2052.2012.02367.x 10.1530/REP-06-0109 10.1095/biolreprod56.2.386 10.1002/(SICI)1098-2795(199610)45:2<231::AID-MRD17>3.0.CO;2-3 10.2527/jas.2008-1728 10.2527/jas1966.253800x 10.1002/(SICI)1098-2795(199802)49:2<168::AID-MRD7>3.0.CO;2-N 10.1530/jrf.0.1020463 10.2527/jas1988.663603x 10.1095/biolreprod64.6.1761 10.1677/joe.0.1650101 10.1530/jrf.0.1030115 10.1095/biolreprod.104.036087 10.1002/mrd.1080370107 10.1016/j.theriogenology.2008.12.015 10.1002/1098-2795(200012)57:4<346::AID-MRD6>3.0.CO;2-M 10.1016/j.theriogenology.2016.04.072 10.1095/biolreprod31.2.332 10.1002/mrd.1153 10.1016/j.theriogenology.2016.08.007 10.1016/j.anireprosci.2020.106302 10.1590/S1516-35982012000900022 10.1016/j.anireprosci.2004.04.020 10.1071/RDv27n1Ab132 10.1530/rep.0.1220601
ContentType	Journal Article
Copyright	2022 Wiley‐VCH GmbH. This article is protected by copyright. All rights reserved. Copyright © 2022 Wiley‐VCH GmbH
Copyright_xml	– notice: 2022 Wiley‐VCH GmbH. – notice: This article is protected by copyright. All rights reserved. – notice: Copyright © 2022 Wiley‐VCH GmbH
DBID	NPM AAYXX CITATION 7QO 8FD FR3 P64 7X8
DOI	10.1111/rda.14164
DatabaseName	PubMed CrossRef Biotechnology Research Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic
DatabaseTitle	PubMed CrossRef Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic
DatabaseTitleList	Engineering Research Database CrossRef PubMed
DeliveryMethod	fulltext_linktorsrc
Discipline	Veterinary Medicine Agriculture
EISSN	1439-0531
EndPage	988
ExternalDocumentID	10_1111_rda_14164 35612981 RDA14164
Genre	article Journal Article
GrantInformation_xml	– fundername: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
GroupedDBID	--- .3N .GA .Y3 05W 0R~ 10A 123 1OB 1OC 29P 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5HH 5LA 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHBH AAHHS AAHTB AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEML ABJNI ABPEJ ABPVW ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFS ACGOD ACIWK ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHEFC AITYG AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AUFTA AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BY8 C45 CAG COF CS3 D-E D-F DCZOG DPXWK DR2 DRFUL DRSTM DU5 EBS ECGQY EJD ESX EYRJQ F00 F01 F04 F5P FEDTE FZ0 G-S G.N GODZA H.T H.X HF~ HGLYW HVGLF HVLQZ HZI HZ~ IHE IX1 J0M K48 LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2W P2X P4D PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ TEORI UB1 V8K W8V W99 WBKPD WIH WIK WOHZO WOIKV WPGGZ WQJ WRC WXSBR XG1 ZZTAW ~IA ~KM ~WT NPM AAMNL AAYXX CITATION 7QO 8FD FR3 P64 7X8
ID	FETCH-LOGICAL-c3534-f870607742c992f8acc893226240a9a98ade24b77c24fe06deb924cbf573da9d3
IEDL.DBID	33P
ISSN	0936-6768
IngestDate	Thu Aug 15 22:23:35 EDT 2024 Thu Oct 10 22:23:41 EDT 2024 Thu Nov 21 21:17:42 EST 2024 Wed Oct 16 00:41:00 EDT 2024 Sat Aug 24 01:00:20 EDT 2024
IsPeerReviewed	true
IsScholarly	true
Issue	9
Keywords	IGFBP 2 embryo quality IVEP oocyte quality caspase-3
Language	English
License	This article is protected by copyright. All rights reserved.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c3534-f870607742c992f8acc893226240a9a98ade24b77c24fe06deb924cbf573da9d3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ORCID	0000-0002-8842-5710 0000-0001-5580-9606 0000-0003-4344-4667 0000-0002-8599-0685
PMID	35612981
PQID	2711156841
PQPubID	26873
PageCount	9
ParticipantIDs	proquest_miscellaneous_2669501855 proquest_journals_2711156841 crossref_primary_10_1111_rda_14164 pubmed_primary_35612981 wiley_primary_10_1111_rda_14164_RDA14164
PublicationCentury	2000
PublicationDate	September 2022
PublicationDateYYYYMMDD	2022-09-01
PublicationDate_xml	– month: 09 year: 2022 text: September 2022
PublicationDecade	2020
PublicationPlace	Germany
PublicationPlace_xml	– name: Germany – name: Oxford
PublicationTitle	Reproduction in domestic animals
PublicationTitleAlternate	Reprod Domest Anim
PublicationYear	2022
Publisher	Blackwell Publishing Ltd
Publisher_xml	– name: Blackwell Publishing Ltd
References	1998; 49 2001; 122 1987; 34 2009; 87 2017; 87 2016; 32 2014; 27 2005; 85 2008; 79 2008; 32 2003; 19 2003; 32 2001; 64 1994; 102 1994; 100 1984; 31 1966; 25 2004; 71 1995; 49 2002; 61 2000; 57 2009; 71 2007; 133 2002; 123 1997; 56 2005; 51 2020; 214 2016; 86 1988; 66 2016; 40 2000; 165 1994; 37 1995; 103 2005; 72 1998; 5 2012; 44 1996; 45 2012; 41 e_1_2_10_23_1 e_1_2_10_24_1 e_1_2_10_21_1 e_1_2_10_20_1 e_1_2_10_40_1 Kinder J. E. (e_1_2_10_17_1) 1987; 34 Varago F. C. (e_1_2_10_36_1) 2008; 32 e_1_2_10_2_1 e_1_2_10_4_1 e_1_2_10_18_1 e_1_2_10_3_1 e_1_2_10_6_1 e_1_2_10_39_1 e_1_2_10_5_1 e_1_2_10_38_1 e_1_2_10_8_1 e_1_2_10_14_1 e_1_2_10_37_1 e_1_2_10_7_1 e_1_2_10_15_1 e_1_2_10_12_1 e_1_2_10_35_1 e_1_2_10_9_1 e_1_2_10_13_1 e_1_2_10_34_1 e_1_2_10_10_1 e_1_2_10_33_1 e_1_2_10_11_1 e_1_2_10_32_1 e_1_2_10_31_1 e_1_2_10_30_1 Lin T. C. (e_1_2_10_19_1) 2003; 19 e_1_2_10_29_1 e_1_2_10_27_1 e_1_2_10_28_1 Kinder J. E. (e_1_2_10_16_1) 1995; 49 e_1_2_10_25_1 Mello R. R. C. (e_1_2_10_22_1) 2016; 40 e_1_2_10_26_1
References_xml	– volume: 71 start-page: 1665 year: 2004 end-page: 1670 article-title: Insulin‐like growth factor‐I as a survival factor for the bovine preimplantation embryo exposed to heat shock publication-title: Biology of Reproduction – volume: 100 start-page: 27 year: 1994 end-page: 33 article-title: Follicular waves and circulating gonadotrophins in 8‐month‐old prepubertal heifers publication-title: Journal of Reproduction and Fertility – volume: 45 start-page: 231 year: 1996 end-page: 239 article-title: Prepubertal bovine oocyte: A negative model for studying oocyte developmental competence publication-title: Molecular Reproduction and Development – volume: 32 start-page: 365 year: 2016 end-page: 385 article-title: Embryo transfer (techniques, donors, and recipients) publication-title: Veterinary Clinics of North America ‐ Food Animal Practice – volume: 72 start-page: 796 year: 2005 end-page: 804 article-title: Relationship between low‐molecular‐weight insulin‐like growth factor‐binding proteins, caspase‐3 activity, and oocyte quality publication-title: Biology of Reproduction – volume: 32 start-page: 106 year: 2003 end-page: 114 article-title: Hormonal stimulation and ultrasound guided transvaginal follicle aspiration and oocyte recovery in Nelore ( ) prepubertal calves publication-title: Revista Brasileira de Zootecnia – volume: 5 start-page: 911 year: 1998 end-page: 919 article-title: Growth factors prevent changes in Bcl‐2 and Bax expression and neuronal apoptosis induced by nitric oxide publication-title: Cell Death and Differentiation – volume: 32 start-page: 100 year: 2008 end-page: 109 article-title: Produção in vitro de embriões bovinos: estado da arte e perspectiva de uma técnica em constante evolução publication-title: Revista Brasileira de Reprodução Animal – volume: 87 start-page: 1971 year: 2009 end-page: 1980 article-title: Evaluation of antral follicle count and ovarian morphology in crossbred beef cows: Investigation of influence of stage of the estrous cycle, age, and birth weight publication-title: Journal of Animal Science – volume: 57 start-page: 346 year: 2000 end-page: 352 article-title: Characterization of embryos derived from calf oocytes: Kinetics of cleavage, cell allocation to inner cell mass, and trophectoderm and lipid metabolism publication-title: Molecular Reproduction and Development – volume: 85 start-page: 53 year: 2005 end-page: 59 article-title: Developmental competence of oocytes from prepubertal crossbred cattle publication-title: Animal Reproduction Science – volume: 51 start-page: 689 year: 2005 end-page: 693 article-title: Relationship between ovarian weight and follicular population in heifers publication-title: Journal of Reproduction and Development – volume: 66 start-page: 603 year: 1988 end-page: 612 article-title: Carcass composition in mature Hereford cows: Estimation and effect on daily metabolizable energy requirement during winter publication-title: Journal of Animal Science – volume: 44 start-page: 91 year: 2012 end-page: 95 article-title: The IGF1 pathway genes and their association with age of puberty in cattle publication-title: Animal Genetics – volume: 64 start-page: 1761 year: 2001 end-page: 1768 article-title: Biochemical and developmental evidence that ooplasmic maturation of prepubertal bovine oocytes is compromised publication-title: Biology of Reproduction – volume: 19 start-page: 4 year: 2003 end-page: 14 article-title: IGF‐I/IGFBP‐I increases blastocyst formation and total blastocyst cell number in mouse embryo culture and facilitates the establishment of a stem‐cell line publication-title: BMC Cell Biology – volume: 34 start-page: 167 year: 1987 end-page: 186 article-title: Endocrine regulation of puberty in cows and ewes publication-title: Journal of Reproduction and Fertility – volume: 133 start-page: 709 year: 2007 end-page: 718 article-title: Temporal detection of caspase‐3 and ‐7 in bovine in vitro procedure embryos of different developmental capacity publication-title: Reproduction – volume: 79 start-page: 1219 year: 2008 end-page: 1225 article-title: Antral follicle count reliably predicts number of morphologically healthy oocytes and follicles in ovaries of young adult cattle publication-title: Biology of Reproduction – volume: 86 start-page: 1240 year: 2016 end-page: 1246 article-title: Effect of cow age on the in vitro developmental competence of oocytes obtained after FSH stimulation and coasting treatments publication-title: Theriogenology – volume: 102 start-page: 463 year: 1994 end-page: 470 article-title: Follicular and hormonal development in prepubertal heifers from 2 to 36 weeks of age publication-title: Journal of Reproduction and Fertility – volume: 122 start-page: 601 year: 2001 end-page: 610 article-title: Changes in the relative abundance of mRNA transcripts for insulin‐like growth factor (IGF‐I and IGF‐II) ligands and their receptors (IGF‐IR/IGF‐IIR) in preimplantation bovine embryos derived from different in vitro systems publication-title: Reproduction – volume: 31 start-page: 332 year: 1984 end-page: 341 article-title: Endocrine mechanisms of puberty in heifers: Estradiol negative feedback regulation of luteinizing hormone secretion publication-title: Biology of Reproduction – volume: 86 start-page: 1308 year: 2016 end-page: 1317 article-title: Morphokinetic‐related response to stress in individually cultured bovine embryos publication-title: Theriogenology – volume: 40 start-page: 58 year: 2016 end-page: 64 article-title: Produção in vitro (PIV) de embriões em bovinos publication-title: Revista Brasileira de Reprodução Animal – volume: 87 start-page: 36 year: 2017 end-page: 47 article-title: Prepubertal heifers versus cows—The differences in the follicular environment publication-title: Theriogenology – volume: 165 start-page: 101 year: 2000 end-page: 113 article-title: Expression of mRNA encoding IGF‐I, IGF‐II and type 1 IGF receptor in bovine ovarian follicles publication-title: Journal of Endocrinology – volume: 214 year: 2020 article-title: Evaluation of ovarian volume by transrectal ultrasonography in cattle; affect of the day of the estrous cycle and validation of a method of subtracting of corpora lutea and follicle volume publication-title: Animal Reproduction Science – volume: 49 start-page: 168 year: 1998 end-page: 175 article-title: Comparative analysis of calf and cow oocytes during in vitro maturation publication-title: Molecular Reproduction and Development – volume: 61 start-page: 234 year: 2002 end-page: 248 article-title: Consequences of bovine oocyte maturation, fertilization or early embryo development in vitro versus in vivo: Implications for blastocyst yield and blastocyst quality publication-title: Molecular Reproduction and Development – volume: 103 start-page: 115 year: 1995 end-page: 120 article-title: Low developmental capacity of in vitro matured and fertilized oocytes from calves compared with that of cows publication-title: Journal of Reproduction and Fertility – volume: 27 start-page: 158 year: 2014 article-title: Vitrification system (open and closed) in new incubator with reduced oxygen publication-title: Reproduction, Fertility and Development – volume: 123 start-page: 789 year: 2002 end-page: 797 article-title: Insulin‐like growth factor (IGF) system in the oocyte and somatic cells of bovine preantral follicles publication-title: Reproduction – volume: 56 start-page: 386 year: 1997 end-page: 392 article-title: Age and hormonal dependence of acquisition of oocyte competence for embryogenesis in prepubertal calves publication-title: Biology of Reproduction – volume: 71 start-page: 1193 year: 2009 end-page: 1208 article-title: Involvement of growth hormone (GH) and insulin‐like growth factor (IGF) system in ovarian folliculogenesis publication-title: Theriogenology – volume: 25 start-page: 800 year: 1966 end-page: 805 article-title: Development and senescence of the postnatal bovine ovary publication-title: Journal of Animal Science – volume: 49 start-page: 393 year: 1995 end-page: 407 article-title: Endocrine basis for puberty in heifers and ewes publication-title: Journal of Reproduction and Fertility – volume: 37 start-page: 48 year: 1994 end-page: 53 article-title: Effect of follicle size on bovine oocyte quality and developmental competence following maturation, fertilization, and culture in vitro publication-title: Molecular Reproduction and Development – volume: 41 start-page: 2129 year: 2012 end-page: 2133 article-title: Effect of breed and corpus luteum on pregnancy rate of bovine embryo recipients publication-title: Revista Brasileira de Zootecnia – ident: e_1_2_10_13_1 doi: 10.1095/biolreprod.108.071670 – ident: e_1_2_10_18_1 doi: 10.1016/j.theriogenology.2016.04.064 – ident: e_1_2_10_23_1 doi: 10.1262/jrd.17014 – ident: e_1_2_10_2_1 doi: 10.1530/jrf.0.1000027 – ident: e_1_2_10_14_1 doi: 10.1095/biolreprod.104.032102 – ident: e_1_2_10_33_1 doi: 10.1590/S1516-35982003000100014 – ident: e_1_2_10_34_1 doi: 10.1038/sj.cdd.4400439 – ident: e_1_2_10_26_1 doi: 10.1016/j.cvfa.2016.01.008 – ident: e_1_2_10_3_1 doi: 10.1530/rep.0.1230789 – ident: e_1_2_10_11_1 doi: 10.1111/j.1365-2052.2012.02367.x – volume: 32 start-page: 100 year: 2008 ident: e_1_2_10_36_1 article-title: Produção in vitro de embriões bovinos: estado da arte e perspectiva de uma técnica em constante evolução publication-title: Revista Brasileira de Reprodução Animal contributor: fullname: Varago F. C. – ident: e_1_2_10_35_1 doi: 10.1530/REP-06-0109 – ident: e_1_2_10_27_1 doi: 10.1095/biolreprod56.2.386 – ident: e_1_2_10_15_1 doi: 10.1002/(SICI)1098-2795(199610)45:2<231::AID-MRD17>3.0.CO;2-3 – ident: e_1_2_10_7_1 doi: 10.2527/jas.2008-1728 – ident: e_1_2_10_9_1 doi: 10.2527/jas1966.253800x – ident: e_1_2_10_12_1 doi: 10.1002/(SICI)1098-2795(199802)49:2<168::AID-MRD7>3.0.CO;2-N – volume: 49 start-page: 393 year: 1995 ident: e_1_2_10_16_1 article-title: Endocrine basis for puberty in heifers and ewes publication-title: Journal of Reproduction and Fertility contributor: fullname: Kinder J. E. – ident: e_1_2_10_10_1 doi: 10.1530/jrf.0.1020463 – ident: e_1_2_10_37_1 doi: 10.2527/jas1988.663603x – volume: 34 start-page: 167 year: 1987 ident: e_1_2_10_17_1 article-title: Endocrine regulation of puberty in cows and ewes publication-title: Journal of Reproduction and Fertility contributor: fullname: Kinder J. E. – ident: e_1_2_10_30_1 doi: 10.1095/biolreprod64.6.1761 – ident: e_1_2_10_4_1 doi: 10.1677/joe.0.1650101 – volume: 19 start-page: 4 year: 2003 ident: e_1_2_10_19_1 article-title: IGF‐I/IGFBP‐I increases blastocyst formation and total blastocyst cell number in mouse embryo culture and facilitates the establishment of a stem‐cell line publication-title: BMC Cell Biology contributor: fullname: Lin T. C. – ident: e_1_2_10_28_1 doi: 10.1530/jrf.0.1030115 – ident: e_1_2_10_24_1 doi: 10.1095/biolreprod.104.036087 – ident: e_1_2_10_20_1 doi: 10.1002/mrd.1080370107 – ident: e_1_2_10_31_1 doi: 10.1016/j.theriogenology.2008.12.015 – ident: e_1_2_10_21_1 doi: 10.1002/1098-2795(200012)57:4<346::AID-MRD6>3.0.CO;2-M – ident: e_1_2_10_32_1 doi: 10.1016/j.theriogenology.2016.04.072 – ident: e_1_2_10_8_1 doi: 10.1095/biolreprod31.2.332 – volume: 40 start-page: 58 year: 2016 ident: e_1_2_10_22_1 article-title: Produção in vitro (PIV) de embriões em bovinos publication-title: Revista Brasileira de Reprodução Animal contributor: fullname: Mello R. R. C. – ident: e_1_2_10_29_1 doi: 10.1002/mrd.1153 – ident: e_1_2_10_38_1 doi: 10.1016/j.theriogenology.2016.08.007 – ident: e_1_2_10_6_1 doi: 10.1016/j.anireprosci.2020.106302 – ident: e_1_2_10_25_1 doi: 10.1590/S1516-35982012000900022 – ident: e_1_2_10_5_1 doi: 10.1016/j.anireprosci.2004.04.020 – ident: e_1_2_10_39_1 doi: 10.1071/RDv27n1Ab132 – ident: e_1_2_10_40_1 doi: 10.1530/rep.0.1220601
SSID	ssj0015877
Score	2.395502
Snippet	The aim of this study was to evaluate the effect of age of Nellore (Bos indicus) donors on the efficiency of in vitro embryo production (IVEP) and pregnancy...
SourceID	proquest crossref pubmed wiley
SourceType	Aggregation Database Index Database Publisher
StartPage	980
SubjectTerms	Age Age factors Blastocysts Bos taurus indicus Calves Caspase caspase‐3 Cattle embryo quality Embryos Estrus cycle Females Follicles Gametocytes IGFBP 2 Insulin-like growth factor-binding protein 2 IVEP oocyte quality Oocytes Pregnancy
Title	Effect of Nellore (Bos indicus) donor age on in‐vitro embryo production and pregnancy rate
URI	https://onlinelibrary.wiley.com/doi/abs/10.1111%2Frda.14164 https://www.ncbi.nlm.nih.gov/pubmed/35612981 https://www.proquest.com/docview/2711156841 https://search.proquest.com/docview/2669501855
Volume	57
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9wwEB4VTuUAZaFlKVQu4gCHSLt-JLZ6Wl7iUlTxEgekyLEdxIEYJSwSN34Cv5Ff0rGTjYpQpUq95TGWI49n_E3G8xlgO-OS2bHGSJULm3DJWSJx2UmEHRlhqTI6klUfn2UnV_LgMNDk_JjVwrT8EP0Pt2AZ0V8HA9dF84eR11ajmSPaR_-LUUIs32C_-gyCkPHURQzY0yRFTN2xCoVdPH3Lt2vRO4D5Fq_GBedo6b8-9RMsdjiTTNqJsQwfXDWAhclN3XFtuAEMLsNWmFiPS352KfYVuG75jIkvyUlIzNSO7Oz5hoTctpk2u8T6ytcE3RDxFT59fX55vH2oPXF3Rf3kyX1LIYvqJrqyeOtuAqfHEwmcFKtwcXR4vn-cdEcwJIYJxpMypEFHCBGpUYqWUhuDAAchGwIBrbSS2jrKiywzlJdulFpXYEBnilJkzGpl2WeYr3zl1oDYjGo91kwLqnhZjpRD9JFKJzl1pjB2CFszZeT3LdNGPotQcADzOIBD2JipKe-MrclphjIilXw8hO_9azSTkPvQlfNTlElTFbgLhRjCl1a9fS8snBCqJLbeiVr8e_f56cEkXqz_u-hX-EhDyUTcl7YB8w_11G3CXGOn3-KM_Q3VE-wH
link.rule.ids	315,782,786,1408,27933,27934,46064,46488
linkProvider	Wiley-Blackwell
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1PTxQxFH8RPIgH1AVkddVqPMBhkt3-mWkTL6tA1ggbo2A4kEw6bYdwYEpmWZK98RH8jH4SXzuzE4kxIfE2f9q06etrf6_vvV8B3mdcMjvSaKlyYRMuOUskbjuJsEMjLFVGR7Lqyfdseir39gNNzodlLkzDD9EduAXNiOt1UPBwIP2HltdWo54j3F-BhzzFiRgSONjXzocgZLx3EU32NEkRVbe8QiGOp6t6dzf6C2LeRaxxyzl48n-dfQrrLdQk42ZuPIMHrurB4_F53dJtuB70foRomJiSS45aL_sGnDWUxsSXZBp8M7UjOx_9jAT3tpnPdon1la8JrkTEV_j11-3Pm4vr2hN3WdQLT64aFlmUONGVxVd3Hmg9FiTQUmzCycH-8adJ0t7CkBgmGE_K4AkdIkqkRilaSm0MYhxEbYgFtNJKausoL7LMUF66YWpdgTadKUqRMauVZVuwWvnKbQOxGdV6pJkWVPGyHCqHACSVTnLqTGFsH94tpZFfNWQb-dJIwQHM4wD2YbCUU97q2yynGZYRqeSjPrztfqOmBPeHrpyfY5k0VYG-UIg-PG_k27XCwiWhSmLtnSjGfzeff9sbx4cX9y_6Bh5Njo8O88PP0y8vYY2GDIoYpjaA1et67l7ByszOX8fp-xvCAPAv
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NbtQwEB7RIqFyKLC0dKEUF_XQHiLt-iexxWlhu2oFXVVQUA-VIsd2qh4ar7JdpN54BJ6RJ2HsZCMqhFSJW37GcuTx2N9kZj4D7GVcMjvU6KlyYRMuOUskbjuJsAMjLFVGR7Lqoy_Z9FyODwNNzrtlLUzDD9H9cAuWEdfrYOAzW_5h5LXVaOaI9lfgIUcYHojzGTvtQghCxmMX0WNPkxRBdUsrFNJ4uqZ3N6O_EOZdwBp3nMmT__rWp7DeAk0yambGM3jgqh48Hl3WLdmG60HvW8iFiQW55KSNsT-Hi4bQmPiSTENkpnZk_72fkxDcNov5AbG-8jXBdYj4Cp_--vHz-9VN7Ym7LupbT2YNhyzqm-jK4q27DKQetySQUmzA18nh2YejpD2DITFMMJ6UIQ46QIxIjVK0lNoYRDiI2RAJaKWV1NZRXmSZobx0g9S6Aj06U5QiY1YryzZhtfKV2wJiM6r1UDMtqOJlOVAO4UcqneTUmcLYPrxdKiOfNVQb-dJFwQHM4wD2YXuppry1tnlOM5QRqeTDPux2r9FOQvBDV84vUCZNVSAvFKIPLxr1dr2wcESokth6P2rx393nn8ejePHy_qJv4NHpeJJ_Op5-fAVrNJRPxBy1bVi9qRfuNazM7WInTt7f45bu1Q
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+Nellore+%28Bos+indicus%29+donor+age+on+in%E2%80%90vitro+embryo+production+and+pregnancy+rate&rft.jtitle=Reproduction+in+domestic+animals&rft.au=Silva%2C+Marina+Oliveira&rft.au=Borges%2C+Marcelo+Sant%27Ana&rft.au=Fernandes%2C+Luana+Gomes&rft.au=Rodrigues%2C+Naiara+Nantes&rft.date=2022-09-01&rft.issn=0936-6768&rft.eissn=1439-0531&rft.volume=57&rft.issue=9&rft.spage=980&rft.epage=988&rft_id=info:doi/10.1111%2Frda.14164&rft.externalDBID=10.1111%252Frda.14164&rft.externalDocID=RDA14164
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0936-6768&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0936-6768&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0936-6768&client=summon