ROS‐ and HIF1α‐dependent IGFBP3 upregulation blocks IGF1 survival signaling and thereby mediates high‐glucose‐induced cardiomyocyte apoptosis

The prevalence of chronic hyperglycemia and its complications, imposing a critical burden on the worldwide economy and the global healthcare system, is a pressing issue. Mounting evidence indicates that oxidative stress and hypoxia, two noticeable features of hyperglycemia, play a joint crucial role...

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Bibliographic Details
Published in:	Journal of cellular physiology Vol. 234; no. 8; pp. 13557 - 13570
Main Authors:	Huang, Yao‐Te, Liu, Chung‐Hung, Yang, Yao‐Chih, Aneja, Ritu, Wen, Su‐Ying, Huang, Chih‐Yang, Kuo, Wei‐Wen
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-08-2019
Subjects:	Animals Apoptosis Apoptosis - physiology Cardiomyocytes Cell Line Cell Survival - physiology Diabetes mellitus diabetic cardiomyopathy Global health Glucose Growth factors Heart HIF1α Hyperglycemia Hyperglycemia - genetics Hyperglycemia - metabolism Hyperglycemia - pathology Hypoxia Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism Insulin Insulin-Like Growth Factor Binding Protein 3 - genetics Insulin-Like Growth Factor Binding Protein 3 - metabolism Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Insulin-like growth factor-binding protein 3 Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Neonates Oxidative stress PHD PI3K/Akt Prolyl hydroxylase Proteins Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism Regulatory mechanisms (biology) Secretion Signal Transduction Survival Up-Regulation Ventricle hyperglycemia hypoxia diabetic cardiomyopathy HIF1α PHD PI3K/Akt
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