Muscle morphology of the lower leg in ambulant children with spastic cerebral palsy

Muscle morphology of the lower leg in ambulant children with spastic cerebral palsy

ABSTRACT Introduction: In this study we aimed to determine the lower limb morphological characteristics of skeletal muscle of ambulant children with spastic cerebral palsy (CP) and typically developing (TD) children. Methods: Seventeen children with spastic diplegic CP (10 boys and 7 girls, 5–12 yea...

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Published in:Muscle & nerve Vol. 58; no. 6; pp. 818 - 823
Main Authors: Pitcher, Christian A., Elliott, Catherine M., Valentine, Jane P., Stannage, Katherine, Williams, Sian A., Shipman, Peter J., Reid, Siobhán L.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-12-2018
Subjects:
Adipose tissue
anatomical cross‐sectional area
Cerebral palsy
Children
Girls
Magnetic resonance imaging
Morphology
MRI
muscle volume
Muscles
Paralysis
Physical characteristics
Skeletal muscle
spastic cerebral palsy
Spasticity
subcutaneous fat
Triceps surae muscle
spastic cerebral palsy
subcutaneous fat
muscle volume
MRI
anatomical cross-sectional area
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Summary:ABSTRACT Introduction: In this study we aimed to determine the lower limb morphological characteristics of skeletal muscle of ambulant children with spastic cerebral palsy (CP) and typically developing (TD) children. Methods: Seventeen children with spastic diplegic CP (10 boys and 7 girls, 5–12 years of age, Gross Motor Function Classification System [GMFCS] level I or II) and 19 TD children (8 boys and 11 girls, 5–11 years of age) underwent lower limb T1‐weighted MRI. Morphological characteristics of the triceps surae, including muscle volume, anatomical cross‐sectional area, muscle length, and subcutaneous adipose tissue, were digitally quantified, and the proportional distribution calculated. Results: Children with GMFCS II had significantly reduced muscle volume, cross‐sectional area, and muscle length, and increased subcutaneous fat compared with TD children. Children classified as GMFCS II consistently exhibited the greatest deficits in all morphology variables. Discussion: Morphological variables were significantly different between the groups. These alterations have the potential to influence the functional capabilities of the triceps surae muscle group. Muscle Nerve 58:818–823, 2018
Bibliography:Conflicts of Interest
This study was supported by the BrightSpark Research Foundation and the Pay‐it‐Forward Foundation (to S.R.), the Raine Medical Research Fellowship; research development awards from the University of Western Australia; and an Australian Postgraduate Award from the University of Western Australia, Perth, WA (to C.P.). The Department of Paediatric Rehabilitation, Princess Margaret Hospital for Children, was recipient of an unrestricted research and postgraduate education grant from Allergan (Irvine, CA, USA).
None of the authors have any conflict of interest to disclose.
Funding
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ISSN:0148-639X
1097-4598
DOI:10.1002/mus.26293