Sestrin2 alleviates palmitate‐induced endoplasmic reticulum stress, apoptosis, and defective invasion of human trophoblast cells

Problem Maternal obesity induces elevated saturated fatty acid palmitate levels in the blood and causes pregnancy complications such as gestational diabetes, preeclampsia, fetal growth abnormalities, and stillbirth. Sestrin2, a highly conserved stress‐inducible protein, is involved in the cellular r...

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Bibliographic Details
Published in:	American journal of reproductive immunology (1989) Vol. 83; no. 4; pp. e13222 - n/a
Main Authors:	Lee, Solji, Shin, Jiha, Hong, Yeji, Shin, Seong Min, Shin, Hye Won, Shin, Jongdae, Lee, Sung Ki, Park, Hwan‐Woo
Format:	Journal Article
Language:	English
Published:	Denmark Wiley Subscription Services, Inc 01-04-2020
Subjects:	Adenylate Kinase - metabolism Animals Apoptosis Bovine serum albumin Cell Movement Cells, Cultured Diabetes mellitus Endoplasmic reticulum Endoplasmic Reticulum Stress Female Fetuses Gestation High fat diet Humans Immunocytochemistry Inflammation Low fat diet Mechanistic Target of Rapamycin Complex 1 - metabolism Mice mRNA Nutrient deficiency Obesity - metabolism Palmitates - metabolism Palmitic acid Peroxidases - metabolism Placenta Pre-eclampsia Pregnancy Pregnancy complications Pregnancy Complications - metabolism Pregnancy Trimester, First saturated fatty acids Signal Transduction Therapeutic applications trophoblast Trophoblasts - metabolism Trophoblasts - pathology placenta saturated fatty acids trophoblast inflammation endoplasmic reticulum stress
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