Exosome‐derived differentiation antagonizing non‐protein coding RNA with risk of hepatitis C virus‐related hepatocellular carcinoma recurrence
Background & Aims Differentiation antagonizing non‐protein coding RNA is associated with various types of neoplasms. Hepatitis C virus‐related hepatocellular carcinoma has a high risk of recurrence. Here we determined the role of differentiation antagonizing non‐protein coding RNA in hepatitis C...
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| Published in: | Liver international Vol. 41; no. 5; pp. 956 - 968 |
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| Language: | English |
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01-05-2021
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| Abstract | Background & Aims
Differentiation antagonizing non‐protein coding RNA is associated with various types of neoplasms. Hepatitis C virus‐related hepatocellular carcinoma has a high risk of recurrence. Here we determined the role of differentiation antagonizing non‐protein coding RNA in hepatitis C virus‐related hepatocarcinogenesis and identified potential therapeutic targets and non‐invasive prognostic markers for long‐term outcome of hepatitis C virus‐related hepatocellular carcinoma after surgical resection.
Methods
Differentiation antagonizing non‐protein coding RNAs relevant to hepatitis C virus‐related hepatocellular carcinoma were identified through comparative RNA‐sequencing of tumour and adjacent non‐tumour (ANT) tissues in a screening set, and were validated using real‐time polymerase chain reaction. Target long non‐coding RNAs (lncRNAs) in tissues and serum exosomes were used to predict the recurrence of hepatitis C virus‐related hepatocellular carcinoma after curative surgical resection in a large application cohort from 2005 to 2012.
Results
We confirmed that differentiation antagonizing non‐protein coding RNA was upregulated following hepatitis C virus infection and identified as the lncRNA most relevant to hepatitis C virus‐related hepatocellular carcinoma in tumour tissues as compared to that in ANT tissues. In 183 hepatitis C virus‐related hepatocellular carcinoma patients followed for 10 years after curative HCC resection, the expression level of circulating exosomal differentiation antagonizing non‐protein coding RNA was positively associated with HCC recurrence and was the most predictive factor associated with HCC recurrence and mortality (hazard ratio/95% confidence intervals: 7.0/4.3‐11.6 and 2.7/1.5‐5.1 respectively).
Conclusions
Differentiation antagonizing non‐protein coding RNA is highly relevant to disease progression of hepatitis C virus‐related hepatocellular carcinoma. Our finding indicated that circulating exosomal differentiation antagonizing non‐protein coding RNA might serve as a non‐invasive prognostic biomarker for hepatitis C virus‐related hepatocellular carcinoma. |
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| AbstractList | Background & Aims
Differentiation antagonizing non‐protein coding RNA is associated with various types of neoplasms. Hepatitis C virus‐related hepatocellular carcinoma has a high risk of recurrence. Here we determined the role of differentiation antagonizing non‐protein coding RNA in hepatitis C virus‐related hepatocarcinogenesis and identified potential therapeutic targets and non‐invasive prognostic markers for long‐term outcome of hepatitis C virus‐related hepatocellular carcinoma after surgical resection.
Methods
Differentiation antagonizing non‐protein coding RNAs relevant to hepatitis C virus‐related hepatocellular carcinoma were identified through comparative RNA‐sequencing of tumour and adjacent non‐tumour (ANT) tissues in a screening set, and were validated using real‐time polymerase chain reaction. Target long non‐coding RNAs (lncRNAs) in tissues and serum exosomes were used to predict the recurrence of hepatitis C virus‐related hepatocellular carcinoma after curative surgical resection in a large application cohort from 2005 to 2012.
Results
We confirmed that differentiation antagonizing non‐protein coding RNA was upregulated following hepatitis C virus infection and identified as the lncRNA most relevant to hepatitis C virus‐related hepatocellular carcinoma in tumour tissues as compared to that in ANT tissues. In 183 hepatitis C virus‐related hepatocellular carcinoma patients followed for 10 years after curative HCC resection, the expression level of circulating exosomal differentiation antagonizing non‐protein coding RNA was positively associated with HCC recurrence and was the most predictive factor associated with HCC recurrence and mortality (hazard ratio/95% confidence intervals: 7.0/4.3‐11.6 and 2.7/1.5‐5.1 respectively).
Conclusions
Differentiation antagonizing non‐protein coding RNA is highly relevant to disease progression of hepatitis C virus‐related hepatocellular carcinoma. Our finding indicated that circulating exosomal differentiation antagonizing non‐protein coding RNA might serve as a non‐invasive prognostic biomarker for hepatitis C virus‐related hepatocellular carcinoma. Abstract Background & Aims Differentiation antagonizing non‐protein coding RNA is associated with various types of neoplasms. Hepatitis C virus‐related hepatocellular carcinoma has a high risk of recurrence. Here we determined the role of differentiation antagonizing non‐protein coding RNA in hepatitis C virus‐related hepatocarcinogenesis and identified potential therapeutic targets and non‐invasive prognostic markers for long‐term outcome of hepatitis C virus‐related hepatocellular carcinoma after surgical resection. Methods Differentiation antagonizing non‐protein coding RNAs relevant to hepatitis C virus‐related hepatocellular carcinoma were identified through comparative RNA‐sequencing of tumour and adjacent non‐tumour (ANT) tissues in a screening set, and were validated using real‐time polymerase chain reaction. Target long non‐coding RNAs (lncRNAs) in tissues and serum exosomes were used to predict the recurrence of hepatitis C virus‐related hepatocellular carcinoma after curative surgical resection in a large application cohort from 2005 to 2012. Results We confirmed that differentiation antagonizing non‐protein coding RNA was upregulated following hepatitis C virus infection and identified as the lncRNA most relevant to hepatitis C virus‐related hepatocellular carcinoma in tumour tissues as compared to that in ANT tissues. In 183 hepatitis C virus‐related hepatocellular carcinoma patients followed for 10 years after curative HCC resection, the expression level of circulating exosomal differentiation antagonizing non‐protein coding RNA was positively associated with HCC recurrence and was the most predictive factor associated with HCC recurrence and mortality (hazard ratio/95% confidence intervals: 7.0/4.3‐11.6 and 2.7/1.5‐5.1 respectively). Conclusions Differentiation antagonizing non‐protein coding RNA is highly relevant to disease progression of hepatitis C virus‐related hepatocellular carcinoma. Our finding indicated that circulating exosomal differentiation antagonizing non‐protein coding RNA might serve as a non‐invasive prognostic biomarker for hepatitis C virus‐related hepatocellular carcinoma. Background & AimsDifferentiation antagonizing non‐protein coding RNA is associated with various types of neoplasms. Hepatitis C virus‐related hepatocellular carcinoma has a high risk of recurrence. Here we determined the role of differentiation antagonizing non‐protein coding RNA in hepatitis C virus‐related hepatocarcinogenesis and identified potential therapeutic targets and non‐invasive prognostic markers for long‐term outcome of hepatitis C virus‐related hepatocellular carcinoma after surgical resection.MethodsDifferentiation antagonizing non‐protein coding RNAs relevant to hepatitis C virus‐related hepatocellular carcinoma were identified through comparative RNA‐sequencing of tumour and adjacent non‐tumour (ANT) tissues in a screening set, and were validated using real‐time polymerase chain reaction. Target long non‐coding RNAs (lncRNAs) in tissues and serum exosomes were used to predict the recurrence of hepatitis C virus‐related hepatocellular carcinoma after curative surgical resection in a large application cohort from 2005 to 2012.ResultsWe confirmed that differentiation antagonizing non‐protein coding RNA was upregulated following hepatitis C virus infection and identified as the lncRNA most relevant to hepatitis C virus‐related hepatocellular carcinoma in tumour tissues as compared to that in ANT tissues. In 183 hepatitis C virus‐related hepatocellular carcinoma patients followed for 10 years after curative HCC resection, the expression level of circulating exosomal differentiation antagonizing non‐protein coding RNA was positively associated with HCC recurrence and was the most predictive factor associated with HCC recurrence and mortality (hazard ratio/95% confidence intervals: 7.0/4.3‐11.6 and 2.7/1.5‐5.1 respectively).ConclusionsDifferentiation antagonizing non‐protein coding RNA is highly relevant to disease progression of hepatitis C virus‐related hepatocellular carcinoma. Our finding indicated that circulating exosomal differentiation antagonizing non‐protein coding RNA might serve as a non‐invasive prognostic biomarker for hepatitis C virus‐related hepatocellular carcinoma. Differentiation antagonizing non-protein coding RNA is associated with various types of neoplasms. Hepatitis C virus-related hepatocellular carcinoma has a high risk of recurrence. Here we determined the role of differentiation antagonizing non-protein coding RNA in hepatitis C virus-related hepatocarcinogenesis and identified potential therapeutic targets and non-invasive prognostic markers for long-term outcome of hepatitis C virus-related hepatocellular carcinoma after surgical resection. Differentiation antagonizing non-protein coding RNAs relevant to hepatitis C virus-related hepatocellular carcinoma were identified through comparative RNA-sequencing of tumour and adjacent non-tumour (ANT) tissues in a screening set, and were validated using real-time polymerase chain reaction. Target long non-coding RNAs (lncRNAs) in tissues and serum exosomes were used to predict the recurrence of hepatitis C virus-related hepatocellular carcinoma after curative surgical resection in a large application cohort from 2005 to 2012. We confirmed that differentiation antagonizing non-protein coding RNA was upregulated following hepatitis C virus infection and identified as the lncRNA most relevant to hepatitis C virus-related hepatocellular carcinoma in tumour tissues as compared to that in ANT tissues. In 183 hepatitis C virus-related hepatocellular carcinoma patients followed for 10 years after curative HCC resection, the expression level of circulating exosomal differentiation antagonizing non-protein coding RNA was positively associated with HCC recurrence and was the most predictive factor associated with HCC recurrence and mortality (hazard ratio/95% confidence intervals: 7.0/4.3-11.6 and 2.7/1.5-5.1 respectively). Differentiation antagonizing non-protein coding RNA is highly relevant to disease progression of hepatitis C virus-related hepatocellular carcinoma. Our finding indicated that circulating exosomal differentiation antagonizing non-protein coding RNA might serve as a non-invasive prognostic biomarker for hepatitis C virus-related hepatocellular carcinoma. |
| Author | Chuang, Wan‐Long Dai, Chia‐Yen Yen, Chia‐Hung Huang, Chung‐Feng Tu, Wen‐Yu Chen, Yao‐Li Yeh, Ming‐Lun Wang, Shu‐Chi Li, Chia‐Yang Lin, Ching‐Chih Huang, Jee‐Fu Chang, Wen‐Tsan Cheng, Wei‐Chung Lin, Zu‐Yau Yu, Ming‐Lung |
| Author_xml | – sequence: 1 givenname: Shu‐Chi orcidid: 0000-0001-9691-7507 surname: Wang fullname: Wang, Shu‐Chi organization: Kaohsiung Medical University – sequence: 2 givenname: Chia‐Yang orcidid: 0000-0001-5689-9850 surname: Li fullname: Li, Chia‐Yang organization: Kaohsiung Medical University – sequence: 3 givenname: Wen‐Tsan surname: Chang fullname: Chang, Wen‐Tsan organization: Kaohsiung Medical University Hospital – sequence: 4 givenname: Wei‐Chung surname: Cheng fullname: Cheng, Wei‐Chung organization: China Medical University – sequence: 5 givenname: Chia‐Hung surname: Yen fullname: Yen, Chia‐Hung organization: Kaohsiung Medical University – sequence: 6 givenname: Wen‐Yu surname: Tu fullname: Tu, Wen‐Yu organization: Kaohsiung Medical University Hospital – sequence: 7 givenname: Zu‐Yau surname: Lin fullname: Lin, Zu‐Yau organization: Kaohsiung Medical University Hospital – sequence: 8 givenname: Ching‐Chih surname: Lin fullname: Lin, Ching‐Chih organization: Kaohsiung Medical University Hospital – sequence: 9 givenname: Ming‐Lun surname: Yeh fullname: Yeh, Ming‐Lun organization: Kaohsiung Medical University – sequence: 10 givenname: Chung‐Feng orcidid: 0000-0002-3367-068X surname: Huang fullname: Huang, Chung‐Feng organization: Kaohsiung Medical University – sequence: 11 givenname: Jee‐Fu orcidid: 0000-0002-2752-7051 surname: Huang fullname: Huang, Jee‐Fu organization: Kaohsiung Medical University – sequence: 12 givenname: Chia‐Yen orcidid: 0000-0003-2296-3054 surname: Dai fullname: Dai, Chia‐Yen organization: Kaohsiung Medical University – sequence: 13 givenname: Wan‐Long surname: Chuang fullname: Chuang, Wan‐Long organization: Kaohsiung Medical University – sequence: 14 givenname: Yao‐Li surname: Chen fullname: Chen, Yao‐Li email: 31560@cch.org.tw, fish6069@gmail.com organization: Changhua Christian Hospital – sequence: 15 givenname: Ming‐Lung orcidid: 0000-0001-8145-1900 surname: Yu fullname: Yu, Ming‐Lung email: 31560@cch.org.tw, fish6069@gmail.com organization: Kaohsiung Medical University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33346937$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1097/MD.0000000000003284 10.1371/journal.pgen.1008181 10.1016/j.jhep.2017.03.011 10.1016/j.jhep.2016.06.015 10.1111/cpr.12628 10.1016/j.jhep.2014.02.022 10.1016/j.prp.2019.01.014 10.1007/s12072-019-09988-7 10.1111/j.0006-341X.2005.030814.x 10.3390/ijms20061406 10.1016/j.jhep.2016.04.008 10.1371/journal.pone.0164281 10.1016/j.biopha.2018.03.105 10.5114/pjp.2015.51148 10.1053/j.gastro.2011.12.061 10.1097/SLA.0000000000000821 10.1016/j.jhep.2016.05.045 10.1007/s11605-016-3344-3 10.1158/1078-0432.CCR-16-0921 10.1111/apt.14823 10.1016/j.prp.2018.04.003 10.1016/j.jhep.2017.04.009 10.1002/hep.27893 10.1002/hep.21363 10.1016/j.jhep.2016.10.035 10.3233/CBM-170727 10.21873/anticanres.11236 10.1038/sj.bjc.6602678 10.1186/s12943-015-0426-x 10.1186/s12866-017-1032-4 10.1002/hep.26195 |
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| Copyright | 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. 2021 John Wiley & Sons A/S |
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| Keywords | recurrence hepatitis C virus differentiation antagonizing non-protein coding RNA HCC exosomes |
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| Notes | Funding information This study was supported by the grants from the Ministry of Science Technology (MOST) grant (108‐2314‐B‐037‐079‐MY3, 106‐2221‐E‐039‐011‐MY3); China Medical University (CMU108‐MF‐93, CMU108‐Z‐02, CMU108‐S‐22); Kaohsiung Medical University (KMU‐Q108009, KMU‐Q109005, 108‐CCH‐KMU‐001); partially by Kaohsiung Medical University Research Center Grant KMU‐TC108A04 and KMU‐TC108B06. Handling Editor: HElen Reeves ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| PublicationTitle | Liver international |
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| References | 2015; 261 2012; 142 2015; 14 2019; 52 2017; 66 2018; 102 2019; 13 2017; 21 2019; 15 2017; 67 2017; 23 2016; 95 2005; 61 2014; 61 2018; 21 2016; 36 2018; 48 2018; 6 2019; 20 2013; 57 2017; 17 2006; 44 2018; 214 2015; 66 2017; 12 2016; 65 2019; 215 2016; 63 2005; 93 2018; 53 e_1_2_13_25_1 e_1_2_13_24_1 e_1_2_13_27_1 e_1_2_13_26_1 e_1_2_13_21_1 e_1_2_13_20_1 e_1_2_13_23_1 e_1_2_13_22_1 e_1_2_13_9_1 e_1_2_13_8_1 e_1_2_13_7_1 e_1_2_13_6_1 e_1_2_13_17_1 e_1_2_13_18_1 e_1_2_13_19_1 e_1_2_13_13_1 e_1_2_13_14_1 e_1_2_13_15_1 e_1_2_13_16_1 e_1_2_13_32_1 e_1_2_13_10_1 e_1_2_13_31_1 e_1_2_13_11_1 e_1_2_13_34_1 e_1_2_13_12_1 e_1_2_13_33_1 e_1_2_13_30_1 Axley P (e_1_2_13_4_1) 2018; 6 e_1_2_13_5_1 e_1_2_13_3_1 e_1_2_13_2_1 Zhang W (e_1_2_13_29_1) 2018; 53 e_1_2_13_28_1 |
| References_xml | – volume: 23 start-page: 1690 issue: 7 year: 2017 end-page: 1697 article-title: Time‐degenerative factors and the risk of hepatocellular carcinoma after antiviral therapy among hepatitis C virus patients: a model for prioritization of treatment publication-title: Clin Cancer Res – volume: 20 start-page: 1406 issue: 6 year: 2019 article-title: Exosomes and hepatocellular carcinoma: from bench to bedside publication-title: Int J Mol Sci – volume: 52 issue: 4 year: 2019 article-title: DANCR promotes HCC progression and regulates EMT by sponging miR‐27a‐3p via ROCK1/LIMK1/COFILIN1 pathway publication-title: Cell Prolif – volume: 14 start-page: 155 year: 2015 article-title: CD90 liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA publication-title: Mol Cancer – volume: 102 start-page: 653 year: 2018 end-page: 669 article-title: Oncogenic long noncoding RNA MALAT1 and HCV‐related hepatocellular carcinoma publication-title: Biomed Pharmacother – volume: 63 start-page: 499 issue: 2 year: 2016 end-page: 511 article-title: Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1 publication-title: Hepatology – volume: 36 start-page: 6389 issue: 12 year: 2016 end-page: 6398 article-title: DANCR acts as a diagnostic biomarker and promotes tumor growth and metastasis in hepatocellular carcinoma publication-title: Anticancer Res – volume: 48 start-page: 127 issue: 2 year: 2018 end-page: 137 article-title: Systematic review with meta‐analysis: recurrence of hepatocellular carcinoma following direct‐acting antiviral therapy publication-title: Aliment Pharmacol Ther – volume: 67 start-page: 302 issue: 2 year: 2017 end-page: 309 article-title: Global trends and predictions in hepatocellular carcinoma mortality publication-title: J Hepatol – volume: 66 start-page: 464 issue: 2 year: 2017 article-title: Unexpected early tumor recurrence in patients with hepatitis C virus‐related hepatocellular carcinoma undergoing interferon‐free therapy: issue of the interval between HCC treatment and antiviral therapy publication-title: J Hepatol – volume: 57 start-page: 1882 issue: 5 year: 2013 end-page: 1892 article-title: Hepatitis B virus X protein (HBx)‐related long noncoding RNA (lncRNA) down‐regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin publication-title: Hepatology – volume: 21 start-page: 651 issue: 3 year: 2018 end-page: 659 article-title: lncRNA‐HEIH in serum and exosomes as a potential biomarker in the HCV‐related hepatocellular carcinoma publication-title: Cancer Biomark – volume: 13 start-page: 649 issue: 6 year: 2019 end-page: 661 article-title: APASL HCV guidelines of virus‐eradicated patients by DAA on how to monitor HCC occurrence and HBV reactivation publication-title: Hepatol Int – volume: 12 issue: 1 year: 2017 article-title: The paradoxical effects of different hepatitis C viral loads on host DNA damage and repair abilities publication-title: PLoS One – volume: 65 start-page: 727 issue: 4 year: 2016 end-page: 733 article-title: Early occurrence and recurrence of hepatocellular carcinoma in HCV‐related cirrhosis treated with direct‐acting antivirals publication-title: J Hepatol – volume: 61 start-page: 67 issue: 1 year: 2014 end-page: 74 article-title: Baseline gamma‐glutamyl transferase levels strongly correlate with hepatocellular carcinoma development in non‐cirrhotic patients with successful hepatitis C virus eradication publication-title: J Hepatol – volume: 67 start-page: 603 issue: 3 year: 2017 end-page: 618 article-title: Non‐coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets publication-title: J Hepatol – volume: 21 start-page: 487 issue: 3 year: 2017 end-page: 495 article-title: Impact of viral etiology on postoperative de novo recurrence after hepatectomy for hepatocellular carcinoma in cirrhotic patients publication-title: J Gastrointest Surg – volume: 17 start-page: 124 issue: 1 year: 2017 article-title: Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/beta‐catenin pathway publication-title: BMC Microbiol – volume: 44 start-page: 1086 issue: 5 year: 2006 end-page: 1097 article-title: A simple noninvasive index for predicting long‐term outcome of chronic hepatitis C after interferon‐based therapy publication-title: Hepatology – volume: 261 start-page: 513 issue: 3 year: 2015 end-page: 520 article-title: A comparison of the surgical outcomes among patients with HBV‐positive, HCV‐positive, and non‐B non‐C hepatocellular carcinoma: a nationwide study of 11,950 patients publication-title: Ann Surg – volume: 215 start-page: 779 issue: 4 year: 2019 end-page: 783 article-title: Serum lincRNA‐p21 expression in primary liver diseases and liver metastatic diseases publication-title: Pathol Res Pract – volume: 66 start-page: 9 issue: 1 year: 2015 end-page: 21 article-title: Alterations of Wnt/beta‐catenin signaling pathway in hepatocellular carcinomas associated with hepatitis C virus publication-title: Pol J Pathol – volume: 65 start-page: 734 issue: 4 year: 2016 end-page: 740 article-title: Lack of evidence of an effect of direct‐acting antivirals on the recurrence of hepatocellular carcinoma: data from three ANRS cohorts publication-title: J Hepatol – volume: 15 issue: 6 year: 2019 article-title: Hepatitis C virus leaves an epigenetic signature post cure of infection by direct‐acting antivirals publication-title: PLoS Genet – volume: 214 start-page: 801 issue: 6 year: 2018 end-page: 805 article-title: LncRNA‐DANCR: a valuable cancer related long non‐coding RNA for human cancers publication-title: Pathol Res Pract – volume: 6 start-page: 79 issue: 1 year: 2018 end-page: 84 article-title: Hepatitis C virus and hepatocellular carcinoma: a narrative review publication-title: J Clin Transl Hepatol – volume: 65 start-page: 719 issue: 4 year: 2016 end-page: 726 article-title: Unexpected high rate of early tumor recurrence in patients with HCV‐related HCC undergoing interferon‐free therapy publication-title: J Hepatol – volume: 142 start-page: 1264 issue: 6 year: 2012 end-page: 1273.e1261 article-title: Epidemiology of viral hepatitis and hepatocellular carcinoma publication-title: Gastroenterology – volume: 93 start-page: 387 issue: 4 year: 2005 end-page: 391 article-title: REporting recommendations for tumour MARKer prognostic studies (REMARK) publication-title: Br J Cancer – volume: 95 issue: 15 year: 2016 article-title: The hepatitis viral status in patients with hepatocellular carcinoma: a study of 3843 patients from Taiwan Liver Cancer Network publication-title: Medicine (Baltimore) – volume: 61 start-page: 92 issue: 1 year: 2005 end-page: 105 article-title: Survival model predictive accuracy and ROC curves publication-title: Biometrics – volume: 53 start-page: 1013 year: 2018 end-page: 1026 article-title: Exosome‐mediated transfer of lncRNA RP11838N2.4 promotes erlotinib resistance in non‐small cell lung cancer publication-title: Int J Oncol – ident: e_1_2_13_17_1 doi: 10.1097/MD.0000000000003284 – ident: e_1_2_13_34_1 doi: 10.1371/journal.pgen.1008181 – ident: e_1_2_13_2_1 doi: 10.1016/j.jhep.2017.03.011 – ident: e_1_2_13_20_1 doi: 10.1016/j.jhep.2016.06.015 – ident: e_1_2_13_24_1 doi: 10.1111/cpr.12628 – ident: e_1_2_13_8_1 doi: 10.1016/j.jhep.2014.02.022 – ident: e_1_2_13_30_1 doi: 10.1016/j.prp.2019.01.014 – ident: e_1_2_13_33_1 doi: 10.1007/s12072-019-09988-7 – ident: e_1_2_13_19_1 doi: 10.1111/j.0006-341X.2005.030814.x – ident: e_1_2_13_22_1 doi: 10.3390/ijms20061406 – ident: e_1_2_13_21_1 doi: 10.1016/j.jhep.2016.04.008 – volume: 6 start-page: 79 issue: 1 year: 2018 ident: e_1_2_13_4_1 article-title: Hepatitis C virus and hepatocellular carcinoma: a narrative review publication-title: J Clin Transl Hepatol contributor: fullname: Axley P – ident: e_1_2_13_18_1 doi: 10.1371/journal.pone.0164281 – ident: e_1_2_13_32_1 doi: 10.1016/j.biopha.2018.03.105 – ident: e_1_2_13_27_1 doi: 10.5114/pjp.2015.51148 – ident: e_1_2_13_3_1 doi: 10.1053/j.gastro.2011.12.061 – ident: e_1_2_13_5_1 doi: 10.1097/SLA.0000000000000821 – ident: e_1_2_13_9_1 doi: 10.1016/j.jhep.2016.05.045 – ident: e_1_2_13_15_1 doi: 10.1007/s11605-016-3344-3 – ident: e_1_2_13_10_1 doi: 10.1158/1078-0432.CCR-16-0921 – ident: e_1_2_13_6_1 doi: 10.1111/apt.14823 – ident: e_1_2_13_23_1 doi: 10.1016/j.prp.2018.04.003 – ident: e_1_2_13_12_1 doi: 10.1016/j.jhep.2017.04.009 – ident: e_1_2_13_13_1 doi: 10.1002/hep.27893 – volume: 53 start-page: 1013 year: 2018 ident: e_1_2_13_29_1 article-title: Exosome‐mediated transfer of lncRNA RP11838N2.4 promotes erlotinib resistance in non‐small cell lung cancer publication-title: Int J Oncol contributor: fullname: Zhang W – ident: e_1_2_13_7_1 doi: 10.1002/hep.21363 – ident: e_1_2_13_11_1 doi: 10.1016/j.jhep.2016.10.035 – ident: e_1_2_13_31_1 doi: 10.3233/CBM-170727 – ident: e_1_2_13_25_1 doi: 10.21873/anticanres.11236 – ident: e_1_2_13_16_1 doi: 10.1038/sj.bjc.6602678 – ident: e_1_2_13_28_1 doi: 10.1186/s12943-015-0426-x – ident: e_1_2_13_26_1 doi: 10.1186/s12866-017-1032-4 – ident: e_1_2_13_14_1 doi: 10.1002/hep.26195 |
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Differentiation antagonizing non‐protein coding RNA is associated with various types of neoplasms. Hepatitis C virus‐related hepatocellular... Differentiation antagonizing non-protein coding RNA is associated with various types of neoplasms. Hepatitis C virus-related hepatocellular carcinoma has a... Abstract Background & Aims Differentiation antagonizing non‐protein coding RNA is associated with various types of neoplasms. Hepatitis C virus‐related... Background & AimsDifferentiation antagonizing non‐protein coding RNA is associated with various types of neoplasms. Hepatitis C virus‐related hepatocellular... BACKGROUND & AIMSDifferentiation antagonizing non-protein coding RNA is associated with various types of neoplasms. Hepatitis C virus-related hepatocellular... |
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| SubjectTerms | Biomarkers Confidence intervals Differentiation differentiation antagonizing non‐protein coding RNA Exosomes Gene sequencing HCC Hepatitis Hepatitis C hepatitis C virus Hepatocellular carcinoma Interferon Liver cancer Neoplasia Neoplasms Non-coding RNA Polymerase chain reaction Proteins recurrence Ribonucleic acid RNA RNA viruses Target recognition Therapeutic targets Tissues Tumors Viruses |
| Title | Exosome‐derived differentiation antagonizing non‐protein coding RNA with risk of hepatitis C virus‐related hepatocellular carcinoma recurrence |
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