Anti‐inflammatory and antinociceptive effects of tilifodiolide, isolated from Salvia tiliifolia Vahl (Lamiaceae)

Salvia tiliifolia Vahl (Lamiaceae) is used for the empirical treatment of pain and inflammation. The diterpenoid tilifodiolide (TFD) was isolated from Salvia tiliifolia. The in vitro anti‐inflammatory effects of TFD (0.1–200 µM) were assessed using murine macrophages stimulated with LPS and estimati...

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Bibliographic Details
Published in:	Drug development research Vol. 79; no. 4; pp. 165 - 172
Main Authors:	González‐Chávez, Marco Martin, Alonso‐Castro, Angel Josabad, Zapata‐Morales, Juan Ramón, Arana‐Argáez, Víctor, Torres‐Romero, Julio Cesar, Medina‐Rivera, Yessica Elisa, Sánchez‐Mendoza, Ernesto, Pérez‐Gutiérrez, Salud
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-06-2018
Subjects:	Acetic acid Analgesics - pharmacology Animals Anti-Inflammatory Agents - pharmacology antinociceptive anti‐inflammatory Carrageenan Dose-Response Relationship, Drug Edema Field tests Formaldehyde In vivo methods and tests Indomethacin Indomethacin - pharmacology Inflammation Interleukin-6 - metabolism Lamiaceae Lipopolysaccharides Locomotor activity Macrophages Macrophages - metabolism Male Mice Motor Activity Naloxone Naloxone - pharmacology Naproxen Naproxen - pharmacology Open-field behavior Pain Pain Measurement - drug effects Pain perception Rodents Rotarod Performance Test Salvia - chemistry Salvia tiliifolia tilifodiolide Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism anti-inflammatory antinociceptive tilifodiolide Salvia tiliifolia
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