Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) agonists in islet transplantation: Endogenous in vivo regulatory T cell expansion promotes prolonged allograft survival

Regulatory T cells (Tregs) modulate alloimmune responses and may facilitate minimization or withdrawal of immunosuppression posttransplant. Current approaches, however, rely on complex ex vivo Treg expansion protocols. Herein, we explore endogenous in vivo Treg expansion through antibody‐mediated ag...

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Bibliographic Details
Published in:	American journal of transplantation Vol. 22; no. 4; pp. 1101 - 1114
Main Authors:	Marfil‐Garza, Braulio A., Pawlick, Rena L., Szeto, Jake, Kroger, Charles, Tahiliani, Vikas, Hefler, Joshua, Dadheech, Nidheesh, Seavey, Mathew M., Wolf, Jeffrey, Jasuja, Rahul R., James Shapiro, A. M.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Limited 01-04-2022
Subjects:	Allografts Animals Antibodies basic (laboratory) research / science Blood glucose costimulation molecule specific Diabetes mellitus endocrinology / diabetology experimental Flow cytometry Graft rejection Graft Rejection - etiology Graft Survival immune regulation Immunoglobulin G Immunohistochemistry Immunological tolerance Immunoregulation immunosuppressant ‐ fusion proteins and monoclonal antibodies Immunosuppression immunosuppression / immune modulation Infiltration Islet cells islet transplantation Islets of Langerhans Transplantation Lymphocytes T Male Metastases Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Monoclonal antibodies Necrosis Pancreas transplants Pancreatic islet transplantation rejection Streptozocin T cell mediated (TCMR) T-Lymphocytes, Regulatory tolerance translational research / science Transplants & implants Tumor necrosis factor Tumor necrosis factor-TNF immunosuppression / immune modulation basic (laboratory) research / science translational research / science endocrinology / diabetology T cell mediated (TCMR) costimulation molecule specific experimental islet transplantation immune regulation immunosuppressant - fusion proteins and monoclonal antibodies rejection tolerance
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