High‐throughput production of liver parenchymal microtissues and enrichment of organ‐specific functions in gelatin methacrylamide microenvironment

Liver parenchymal microtissues (LPMTs) are three‐dimensional (3D) aggregates of hepatocytes that recapitulate in vivo‐like cellular assembly. They are considered as a valuable model to study drug metabolism, disease biology, and serve as ideal building blocks for liver tissue engineering. However, t...

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Bibliographic Details
Published in:	Biotechnology and bioengineering Vol. 119; no. 3; pp. 1018 - 1032
Main Authors:	Roopesh, Ramesh Pai, Muthusamy, Senthilkumar, Velayudhan, Shiny, Sabareeswaran, Arumugham, Anil Kumar, Pallickaveedu RajanAsari
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-03-2022
Subjects:	Albumins bioprinting Cell culture Cell size Cell viability Chambers Cytochrome P450 Cytochromes P450 Droplets Drug metabolism Drug screening Gelatin gelatin methacrylamide hanging‐drop culture Hepatocytes Hydrogels Insulin Liver Mass production Methacrylamide Microenvironments microtissues Multidrug resistance Polarity Polyethylene Polyethylene terephthalate sandwich culture Structural integrity Structure-function relationships Substrates Three dimensional printing Tissue engineering Urea Zonula occludens-1 protein sandwich culture hanging-drop culture gelatin methacrylamide bioprinting microtissues
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