New procedure to fortify fluid milk with iron: Metabolic and biochemical study in rats

• Published in: Nutrition research (New York, N.Y.) Vol. 16; no. 1; pp. 131 - 137
• Main Authors: Zubillaga, Marcela B., Caro, Ricardo A., Boccio, JoséR., Gotelli, Carlos A., Gotelli, Mariano J., Weill, Ricardo
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 1996; Elsevier Science
• Subjects: ABSORCION; ABSORCION DE SUSTANCIAS NUTRITIVAS; ABSORCION DIGESTIVA; ABSORPTION; ABSORPTION DE SUBSTANCES NUTRITIVES; ABSORPTION DIGESTIVE; BAZO; Biological and medical sciences; CIRCULACION SANGUINEA; CIRCULATION SANGUINE; COMPLEMENT ALIMENTAIRE; DIETA; ERITROCITOS; ERYTHROCYTE; FER; Ferrous sulfate; FOIE; Food industries; Fortification; Fundamental and applied biological sciences. Psychology; HEMOGLOBINA; HEMOGLOBINE; HIERRO; HIGADO; HUESOS; INSTRUMENT DE MESURE; INSTRUMENTOS DE MEDICION; INTESTIN; INTESTINOS; Iron; LAIT; LECHE; Metabolism; METABOLISME; METABOLISMO; Milk; Milk and cheese industries. Ice creams; NUTRIENTES; NUTRIENTES MINERALES; PORFIRINAS; PORPHYRINE; PROCESAMIENTO; RAT; RATA; RATE; Rats; REGIME ALIMENTAIRE; REIN; RINONES; SANG; SANGRE; SUBSTANCE NUTRITIVE; SUBSTANCE NUTRITIVE MINERALE; SUPLEMENTOS; TRAITEMENT; TRANSPORT DES SUBSTANCES NUTRITIVES; TRANSPORTE DE NUTRIENTES; VIA BIOQUIMICA DEL METABOLISMO; VOIE BIOCHIMIQUE DU METABOLISME; Rats; Iron; Ferrous sulfate; Metabolism; Fortification; Milk; Encapsulation; Pasteurized milk; Nutrition; Rat; Rodentia; Gut; Dairy product; Phospholipid; Bioavailability; Inorganic element; Fortified product; Vertebrata; Mammalia; Absorption; Iron Sulfates
• DOI: 10.1016/0271-5317(95)02067-5
• EISSN: 1879-0739
• ISSN: 0271-5317

A comparative study with two groups of 25 rats each was undertaken in order to study fluid milk fortified with SFE-171 (stabilized FeSO
4 by micro encapsulation with phospholipids) or FeSO
4, both labeled with
59Fe. After the administration of either product, its total absorption, biodistribution and incorporation of iron into hemoglobin was determined for both cases. In the first case the total absorption was (28.3 ± 6.0)%, whereas in the second it was (24.1 ± 5.8)%, the difference between both values is statistically significant with a P < 0.01. The biodistribution results show that the iron from SFE-171 follows the same metabolic pathway than that from FeSO
4. The highest amount (approximately 80%) was found in blood, followed by the liver with approximately 11% and bones with a proportion somewhat higher than 4%, the activity in intestine was minimal in both cases. The
59Fe in blood was found 18 days after the administration of either product at a 100% in the red blood cells, which implies that the iron administered in the milk fortified with SFE-171 or with FeSO
4 was incorporated into hemoglobin. These results indicate with a high degree of significance that the fortification of milk with SFE-171 is a procedure which assures the effective absorption of iron and a physiological behavior of this element.