Baroreflex responses to activity at different temperatures in the South American rattlesnake, Crotalus durissus

• Published in: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology Vol. 191; no. 5; pp. 917 - 925
• Main Authors: Filogonio, Renato, Neto, Antônio V. G. S., Zamponi, Mariana M., Abe, Augusto S., Leite, Cléo A. C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-09-2021; Springer Nature B.V
• Subjects: Animal Physiology; Baroreceptors; Biochemistry; Biomedical and Life Sciences; Biomedicine; Blood pressure; Body temperature; Buffers; Crotalus durissus; Decay rate; Diastole; Heart rate; Human Physiology; Hypertension; Life Sciences; Original Paper; Physical exercise; Reflexes; Reptiles; Snakes; Time constant; Zoology; Time constant of pressure decay; Oscillatory power fraction; Baroreflex effectiveness index; Sequence method
• ISSN: 0174-1578; 1432-136X
• DOI: 10.1007/s00360-021-01396-4

In humans, physical exercise imposes narrower limits for the heart rate (
f
H
) response of the baroreflex, and vascular modulation becomes largely responsible for arterial pressure regulation. In undisturbed reptiles, the baroreflex-related
f
H
alterations at the operating point (
G
op
) decreases at elevated body temperatures (
T
b
) and the vascular regulation changes accordingly. We investigated how the baroreflex of rattlesnakes,
Crotalus durissus
, is regulated during an activity at different
T
b
, expecting that activity would reduce the capacity of the cardiac baroreflex neural pathway to buffer arterial pressure fluctuations while being compensated by the vascular neural pathway regulation. Snakes were catheterized for blood pressure assessment at three different
T
b
: 15, 20 and 30 °C. Data were collected before and after activity at each
T
b
. Baroreflex gain (
G
op
) was assessed with the sequence method; the vascular limb, with the time constant of pressure decay (
τ
), using the two-element
Windkessel
equation
.
Both
G
op
and
τ
reduced when
T
b
increased. Activity also reduced
G
op
and
τ
in all
T
b
. The relationship between
τ
and pulse interval (
τ
/PI) was unaffected by the temperature at resting snakes, albeit it reduced after activity at 20 °C and 30 °C. The unchanged
τ
/PI and normalized
G
op
at different
T
b
indicated those variables are actively adjusted to work at different
f
H
and pressure conditions at rest. Our data suggest that during activity, the baroreflex-related
f
H
response is attenuated and hypertension is buffered by a disproportional increase in the rate which pressure decays during diastole. This compensation seems especially important at higher
T
b
where
G
op
is already low.