Intra-amniotic inflammatory complications in preterm prelabor rupture of membranes and long-term neurodevelopmental outcomes of infants: a systematic review

• Published in: The journal of maternal-fetal & neonatal medicine Vol. 35; no. 25; pp. 5993 - 5998
• Main Authors: Burckova, Hana, Stranik, Jaroslav, Musilova, Ivana, Matulova, Jana, Jacobsson, Bo, Kacerovsky, Marian
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 12-12-2022
• Subjects: Amniocentesis; cerebral palsy; cognitive; intra-amniotic inflammation; microbial invasion of the amniotic cavity; morbidity; neurodevelopment; Obstetrics, Gynecology and Reproductive Medicine; preterm labor; psycho-motoric; Reproduktionsmedicin och gynekologi; intra-amniotic inflammation; Amniocentesis; cognitive; neurodevelopment; cerebral palsy; preterm labor; microbial invasion of the amniotic cavity; morbidity; psycho-motoric
• ISSN: 1476-7058; 1476-4954; 1476-4954
• DOI: 10.1080/14767058.2021.1903859

To perform a systematic review of the literature available on the association between the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation and long-term neurodevelopmental outcomes of infants from pregnancies complicated by preterm prelabor rupture of membranes (PPROM).
A literature search, from their earliest entries to May 2020, was performed by employing three electronic databases (Web of Science, PubMed, and Scopus). The selection criteria were as follows: (1) singleton pregnancies with PPROM; (2) available information regarding MIAC and/or intra-amniotic inflammation; (3) long-term (at least one year of the corrected age) neurodevelopmental outcomes of respective infants.
The initial search identified 10,953 articles, of which 8 were selected for full-text reading; however, none were included in the review owing to the following reasons: (i) spontaneous preterm labor with intact membranes and/or indicated (iatrogenic) preterm delivery were included in the studies without providing separate data for PPROM (n = 5); (ii) long-term, at least one year of the corrected age, neurodevelopmental outcomes of infants were not assessed (n = 1); (iii) the presence of both the abovementioned reasons (n = 1); (iv) amniotic fluid was not assessed, and a long-term neurodevelopmental outcome was not evaluated (n = 1).
The literature search provides evidence of a knowledge gap in the association between the presence of MIAC and/or intra-amniotic inflammation and long-term neurodevelopmental outcomes in infants with PPROM.