Physical Exercise and Liver Autophagy: Potential Roles of IL-6 and Irisin

Physical Exercise and Liver Autophagy: Potential Roles of IL-6 and Irisin

Autophagic dysregulation contributes to liver diseases. Although some investigations have examined the effects of endurance and resistance exercise on autophagy activation, potential myokines responsible for skeletal muscle–liver crosstalk are still unknown. Based on experimental studies and bioinfo...

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Bibliographic Details
Published in:Exercise and sport sciences reviews Vol. 50; no. 2; pp. 89 - 96
Main Authors: Pinto, Ana P., Ropelle, Eduardo R., Quadrilatero, Joe, da Silva, Adelino S. R.
Format: Journal Article
Language:English
Published: United States Lippincott Williams & Wilkins 01-04-2022
Subjects:
Autophagy
Exercise
Fibronectins - physiology
Humans
Interleukin-6 - physiology
Liver
Muscle, Skeletal
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Summary:Autophagic dysregulation contributes to liver diseases. Although some investigations have examined the effects of endurance and resistance exercise on autophagy activation, potential myokines responsible for skeletal muscle–liver crosstalk are still unknown. Based on experimental studies and bioinformatics, we hypothesized that interleukin 6 (IL-6) and irisin might be key players in the contraction-induced release of molecules that regulate liver autophagic responses.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0091-6331
1538-3008
DOI:10.1249/JES.0000000000000278