High infiltration of B cells in tertiary lymphoid structures, TCR oligoclonality, and neoantigens are part of esophageal squamous cell carcinoma microenvironment

Esophageal squamous cell carcinoma (ESCA) exhibits high intratumoral molecular heterogeneity posing a challenge to cancer therapy. Immune checkpoint blockade therapy has been approved for this disease, but with modest results. RNA‐Seq data from paired tumor and surrounding nonmalignant tissue from 1...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 108; no. 4; pp. 1307 - 1318
Main Authors:	Barros, Luciana Rodrigues Carvalho, Souza‐Santos, Paulo Thiago De, Pretti, Marco Antonio Marques, Vieira, Gustavo Fioravanti, Bragatte, Marcelo Alves De Souza, Mendes, Marcus Fabiano De Almeida, De Freitas, Martiela Vaz, Scherer, Nicole De Miranda, De Oliveira, Ivanir Martins, Rapozo, Davy Carlos Mendes, Fernandes, Priscila Valverde, Simão, Tatiana De Almeida, Soares‐Lima, Sheila Coelho, Boroni, Mariana, Ribeiro Pinto, Luis Felipe, Bonamino, Martin Hernan
Format:	Journal Article
Language:	English
Published:	United States 01-10-2020
Subjects:	Antigens, Neoplasm - immunology B-Lymphocytes - immunology B-Lymphocytes - pathology esophageal cancer Esophageal Neoplasms - immunology Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma - immunology Esophageal Squamous Cell Carcinoma - pathology Female Humans Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Male neoantigens oncoimmunology Receptors, Antigen, T-Cell - immunology RNA-Seq Tertiary Lymphoid Structures - immunology Tertiary Lymphoid Structures - pathology Tumor Microenvironment - immunology tumor‐infiltrating lymphocytes neoantigens tumor-infiltrating lymphocytes esophageal cancer oncoimmunology
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