Matrix metalloproteinase 1 promoter polymorphisms and risk of myocardial infarction: a case-control study in a Spanish population
Inherited and acquired risk factors contribute to the development of the atherosclerotic lesion and its most common clinical manifestation, myocardial infarction (MI). Multiple studies have suggested a role for matrix metalloproteinases (MMPs) in atherosclerosis, and several functional polymorphisms...
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| Published in: | Coronary artery disease Vol. 20; no. 6; pp. 383 - 386 |
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01-09-2009
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| Abstract | Inherited and acquired risk factors contribute to the development of the atherosclerotic lesion and its most common clinical manifestation, myocardial infarction (MI). Multiple studies have suggested a role for matrix metalloproteinases (MMPs) in atherosclerosis, and several functional polymorphisms in the MMP-1 gene have been linked to the risk of MI. The aim of this study was to evaluate the association between MMP-1 promoter polymorphisms and early MI in a Spanish cohort.
We carried out a case-control study with 261 unrelated patients who had suffered an MI before 55 years of age and 194 healthy controls, all male and smokers. The genotypes for the three MMP-1 promoter polymorphisms -1607 1G/2G, -519 A/G, and -340 T/C were determined through PCR-restriction fragment length polymorphism. Allelic, genotypic, and haplotypic frequencies were statistically compared between groups.
Frequencies of the three polymorphisms did not differ between patients and controls. The -1607 1G/2G and -519 A/G variants were in linkage disequilibrium. Analysis of the haplotype frequencies showed significant associations of the 2G(-1607)-G(-519)-T(-340) (odds ratio = 2.40; 95% confidence interval = 1.27-4.55; P<0.006) and 1G(-1607)-G(-519)-T(-340) (odds ratio = 0.68; 95% confidence interval = 0.50-0.94; P<0.05) haplotypes with the risk of early MI.
MMP-1 promoter polymorphisms are associated with the risk of early MI in a Spanish population of smoking males. |
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| AbstractList | Inherited and acquired risk factors contribute to the development of the atherosclerotic lesion and its most common clinical manifestation, myocardial infarction (MI). Multiple studies have suggested a role for matrix metalloproteinases (MMPs) in atherosclerosis, and several functional polymorphisms in the MMP-1 gene have been linked to the risk of MI. The aim of this study was to evaluate the association between MMP-1 promoter polymorphisms and early MI in a Spanish cohort.
We carried out a case-control study with 261 unrelated patients who had suffered an MI before 55 years of age and 194 healthy controls, all male and smokers. The genotypes for the three MMP-1 promoter polymorphisms -1607 1G/2G, -519 A/G, and -340 T/C were determined through PCR-restriction fragment length polymorphism. Allelic, genotypic, and haplotypic frequencies were statistically compared between groups.
Frequencies of the three polymorphisms did not differ between patients and controls. The -1607 1G/2G and -519 A/G variants were in linkage disequilibrium. Analysis of the haplotype frequencies showed significant associations of the 2G(-1607)-G(-519)-T(-340) (odds ratio = 2.40; 95% confidence interval = 1.27-4.55; P<0.006) and 1G(-1607)-G(-519)-T(-340) (odds ratio = 0.68; 95% confidence interval = 0.50-0.94; P<0.05) haplotypes with the risk of early MI.
MMP-1 promoter polymorphisms are associated with the risk of early MI in a Spanish population of smoking males. OBJECTIVESInherited and acquired risk factors contribute to the development of the atherosclerotic lesion and its most common clinical manifestation, myocardial infarction (MI). Multiple studies have suggested a role for matrix metalloproteinases (MMPs) in atherosclerosis, and several functional polymorphisms in the MMP-1 gene have been linked to the risk of MI. The aim of this study was to evaluate the association between MMP-1 promoter polymorphisms and early MI in a Spanish cohort.METHODSWe carried out a case-control study with 261 unrelated patients who had suffered an MI before 55 years of age and 194 healthy controls, all male and smokers. The genotypes for the three MMP-1 promoter polymorphisms -1607 1G/2G, -519 A/G, and -340 T/C were determined through PCR-restriction fragment length polymorphism. Allelic, genotypic, and haplotypic frequencies were statistically compared between groups.RESULTSFrequencies of the three polymorphisms did not differ between patients and controls. The -1607 1G/2G and -519 A/G variants were in linkage disequilibrium. Analysis of the haplotype frequencies showed significant associations of the 2G(-1607)-G(-519)-T(-340) (odds ratio = 2.40; 95% confidence interval = 1.27-4.55; P<0.006) and 1G(-1607)-G(-519)-T(-340) (odds ratio = 0.68; 95% confidence interval = 0.50-0.94; P<0.05) haplotypes with the risk of early MI.CONCLUSIONMMP-1 promoter polymorphisms are associated with the risk of early MI in a Spanish population of smoking males. |
| Author | Coto, Eliecer Román-García, Pablo Lozano, Iñigo Morís, César Reguero, Julián R Avanzas, Pablo Rodríguez, Isabel Cannata-Andía, Jorge B |
| Author_xml | – sequence: 1 givenname: Pablo surname: Román-García fullname: Román-García, Pablo organization: Servicio de Metabolismo Oseo y Mineral, Hospital Universitario Central de Asturias, Oviedo, Spain – sequence: 2 givenname: Eliecer surname: Coto fullname: Coto, Eliecer – sequence: 3 givenname: Julián R surname: Reguero fullname: Reguero, Julián R – sequence: 4 givenname: Jorge B surname: Cannata-Andía fullname: Cannata-Andía, Jorge B – sequence: 5 givenname: Iñigo surname: Lozano fullname: Lozano, Iñigo – sequence: 6 givenname: Pablo surname: Avanzas fullname: Avanzas, Pablo – sequence: 7 givenname: César surname: Morís fullname: Morís, César – sequence: 8 givenname: Isabel surname: Rodríguez fullname: Rodríguez, Isabel |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19620856$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Adult Case-Control Studies Gene Frequency Genetic Predisposition to Disease Haplotypes Humans Linkage Disequilibrium Male Matrix Metalloproteinase 1 - genetics Middle Aged Myocardial Infarction - enzymology Myocardial Infarction - genetics Odds Ratio Polymorphism, Genetic Promoter Regions, Genetic Risk Assessment Risk Factors Sex Factors Smoking - adverse effects Spain |
| Title | Matrix metalloproteinase 1 promoter polymorphisms and risk of myocardial infarction: a case-control study in a Spanish population |
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