Magnetic resonance of polyaspartic acid-coated magnetite nanoparticles administered in mice

• Published in: IEEE transactions on magnetics Vol. 41; no. 10; pp. 4108 - 4110
• Main Authors: Sadeghiani, N., Barbosa, L.S., Guedes, M.H.A., Chaves, S.B., Santos, J.G., Silva, O., Pelegrini, F., Azevedo, R.B., Morais, P.C., Lacava, Z.G.M.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY IEEE 01-10-2005; Institute of Electrical and Electronics Engineers; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Blood; Cross-disciplinary physics: materials science; rheology; Exact sciences and technology; Genetics; Kinetic theory; Liver; Lungs; Magnetic fluid (MF); Magnetic liquids; Magnetic resonance; magnetic resonance (MR); Magnetism; Materials science; Mice; Microscopy; nanoparticle biodistribution; Nanoparticles; Other topics in materials science; Physics; polyaspartic acid (PA); Nanoparticles; Magnetite; Magnetic resonance; nanoparticle biodistribution; polyaspartic acid (PA); Aspartic acid; magnetic resonance (MR); Magnetic fluid (MF); Magnetic fluids; Magnetic properties
• ISSN: 0018-9464; 1941-0069
• DOI: 10.1109/TMAG.2005.855334

Magnetic resonance (MR) was used in the biodistribution investigation of magnetic nanoparticles (MNPs) surface-coated with polyaspartic acid (PAMF), developed as a biocompatible magnetic fluid (BMF) sample. The data allowed us to obtain the kinetic parameters for MNP disposition from the blood and its uptake by the liver, spleen, and lungs. Light microscopy confirmed the MR results. Genetic and toxicity tests showed that the PAMF is reasonable biocompatible. The PAMF sample presented peculiar biodistribution patterns and may be considered as a potential precursor of anticancer drugs.