Carcinosarcomatous malignancy, osteosarcoma and squamous cell carcinoma, in giant cell tumor of the right distal femur

• Published in: Pathology, research and practice Vol. 204; no. 8; pp. 583 - 588
• Main Authors: Machinami, Rikuo, Nishida, Kazunori, Ishida, Tsuyoshi, Matsumoto, Seiichi, Kuroda, Kouji, Kobayashi, Masafumi, Takeuchi, Kengo, Ishikawa, Yuichi
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01-01-2008
• Subjects: Amputation; Bone Transplantation; Carcinoma, Squamous Cell - diagnostic imaging; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Carcinosarcoma; Carcinosarcoma - diagnostic imaging; Carcinosarcoma - pathology; Carcinosarcoma - surgery; Curettage; Fatal Outcome; Femoral Neoplasms - diagnostic imaging; Femoral Neoplasms - pathology; Femoral Neoplasms - surgery; Giant cell tumor; Giant Cell Tumor of Bone - diagnostic imaging; Giant Cell Tumor of Bone - pathology; Giant Cell Tumor of Bone - surgery; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence, Local; Osteosarcoma; Osteosarcoma - diagnostic imaging; Osteosarcoma - pathology; Osteosarcoma - surgery; Radiography; Squamous cell carcinoma; Terminology as Topic; Squamous cell carcinoma; Giant cell tumor; Osteosarcoma; Carcinosarcoma
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2008.02.002

We report a new type of secondary malignant giant cell tumor of bone, the malignancy of which was assigned to a carcinosarcoma, i.e., osteosarcoma and squamous cell carcinoma. It occurred 25 years after curettage and bone graft surgery under the diagnosis of giant cell tumor of the right distal femur. Although secondary malignant giant cell tumor is known as a sarcoma arising at the site of a previously diagnosed giant cell tumor, this case should be regarded as a new type of secondary malignant giant cell tumor of bone.