Uncoupling proteins: Targets of endocrine disruptors?

The roles of uncoupling proteins (UCPs) are discussed. Particular attention has been paid to the roles of UCP2 to UCP5 as agents mediating thermogenesis, and to the concept of limited or “mild” uncoupling as a means of reducing oxidative stress. The role of the endocrine system, thyroid hormones and...

Full description

Saved in:

Bibliographic Details
Published in:	Molecular and cellular endocrinology Vol. 244; no. 1; pp. 79 - 86
Main Authors:	Pawade, T., Ho, P.W.L., Kwok, K.H.-H., Chu, A.C.-Y., Ho, S.-L., Ramsden, D.B.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01-12-2005
Subjects:	Adenosine Triphosphate - metabolism Animals ATP Carrier Proteins - physiology Catecholamines - physiology Electron transport Endocrine Disruptors - pharmacology Humans Ion Channels Membrane Proteins - physiology Membrane Transport Proteins - physiology Mitochondrial Proteins - physiology Oxidative phosphorylation Oxidative Stress - physiology Thermogenesis - physiology Thyroid Hormones - physiology Uncoupling Agents Uncoupling protein Uncoupling Protein 1 Uncoupling Protein 2 Uncoupling Protein 3 Uncoupling protein Oxidative phosphorylation Electron transport ATP
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The roles of uncoupling proteins (UCPs) are discussed. Particular attention has been paid to the roles of UCP2 to UCP5 as agents mediating thermogenesis, and to the concept of limited or “mild” uncoupling as a means of reducing oxidative stress. The role of the endocrine system, thyroid hormones and catecholamines, in regulating expression of UCPs is also discussed.
ISSN:	0303-7207 1872-8057
DOI:	10.1016/j.mce.2005.06.008