Subtle blood‐brain barrier leakage rate and spatial extent: Considerations for dynamic contrast‐enhanced MRI

Purpose Dynamic contrast‐enhanced (DCE) MRI can be used to measure blood‐brain barrier (BBB) leakage. In neurodegenerative disorders such as small vessel disease and dementia, the leakage can be very subtle and the corresponding signal can be rather noisy. For these reasons, an optimized DCE‐MRI mea...

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Bibliographic Details

Published in:	Medical physics (Lancaster) Vol. 44; no. 8; pp. 4112 - 4125
Main Authors:	Haar, Harm J., Jansen, Jacobus F.A., Jeukens, Cécile R.L.P.N., Burgmans, Saartje, Buchem, Mark A., Muller, Majon, Hofman, Paul A.M., Verhey, Frans R.J., Osch, Matthias J.P., Backes, Walter H.
Format:	Journal Article
Language:	English
Published:	United States 01-08-2017
Subjects:	Alzheimer's disease Blood-Brain Barrier brain MRI Contrast Media - pharmacokinetics dynamic contrast‐enhanced MRI, leakage Gray Matter Humans Magnetic Resonance Imaging pharmacokinetic modeling White Matter blood-brain barrier brain MRI Alzheimer's disease dynamic contrast-enhanced MRI, leakage pharmacokinetic modeling
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