A Comparative Clinical Study Focusing on the Antimicrobial Efficacies of Chlorhexidine Gluconate Alcohol for Patient Skin Preparations

• Published in: Journal of infusion nursing Vol. 35; no. 1; pp. 44 - 50
• Main Authors: Nishihara, Yutaka, Kajiura, Takumi, Katsuhiro, Yokota, Kobayashi, Hiroyoshi, Okubo, Takashi
• Format: Journal Article
• Language: English
• Published: United States Copyright by the Infusion Nurses Society 01-01-2012
• Subjects: Analysis of Variance; Anti-Infective Agents - therapeutic use; Anti-Infective Agents, Local - therapeutic use; Chlorhexidine - analogs & derivatives; Chlorhexidine - therapeutic use; Colony Count, Microbial; Humans; Japan; Methicillin-Resistant Staphylococcus aureus; Nursing; Patient Care; Skin - drug effects; Skin - microbiology; Statistics as Topic; Statistics, Nonparametric; Japan
• ISSN: 1533-1458; 1539-0667
• DOI: 10.1097/NAN.0b013e31823d79ba

Comparative efficacy study data showed that skin preparations formulated with more than 0.5% chlorhexidine gluconate (CHG) in alcohol produced significant reductions in microbial populations at the inguinal, abdominal, and antecubital sites at each sample time (P < .05) relative to baseline, and there were no significant differences statistically, including persistent effects within 24 hours (P > .05). It would be reasonable to expect that a 1% CHG-ethanol skin preparation (with >0.5% GHC in alcohol) could be chosen in Japan that would perform well and have promising potential for catheter preparation/maintenance preparation with consideration for recommendation of the Centers for Disease Control and Preventionʼs guideline dssuei in 2011.