Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery

This report addresses the continuing need for increased throughput in the evaluation of new chemical entities (NCEs) in terms of their pharmacokinetic (PK) parameters by describing an alternative procedure for increasing the throughput of the in vivo screening of NCEs in the oral rat PK model. The n...

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Bibliographic Details

Published in:	Rapid communications in mass spectrometry Vol. 15; no. 5; pp. 335 - 340
Main Authors:	Korfmacher, Walter A., Cox, Kathleen A., Ng, Kwokei J., Veals, John, Hsieh, Yunsheng, Wainhaus, Sam, Broske, Lisa, Prelusky, Dan, Nomeir, Amin, White, Ronald E.
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-01-2001
Subjects:	Administration, Oral Animals Area Under Curve Chromatography, High Pressure Liquid Drug Evaluation, Preclinical - methods Male Mass Spectrometry Pharmacokinetics Pharmacology Rats Rats, Sprague-Dawley
Online Access:	Get full text
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