Circulating nucleosomes and response to chemotherapy: An in vitro, in vivo and clinical study on cervical cancer patients

It is known that cell‐free DNA circulates in plasma/serum of patients with cancer and that part of this DNA circulates as nucleosomes that can be quantified by ELISA. We analyzed the effect of tumor and chemotherapy upon the levels of nucleosomes in vitro, in vivo and in cervical cancer patients. Th...

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Bibliographic Details
Published in:	International journal of cancer Vol. 104; no. 6; pp. 663 - 668
Main Authors:	Trejo‐Becerril, Catalina, Pérez‐Cárdenas, Enrique, Treviño‐Cuevas, Homero, Taja‐Chayeb, Lucía, García‐López, Patricia, Segura‐Pacheco, Blanca, Chávez‐Blanco, Alma, Lizano‐Soberon, Marcela, González‐Fierro, Aurora, Mariscal, Ignacio, Wegman‐Ostrosky, Talia, Dueñas‐González, Alfonso
Format:	Journal Article
Language:	English
Published:	New York Wiley Subscription Services, Inc., A Wiley Company 10-05-2003 Wiley-Liss
Subjects:	Adenocarcinoma - blood Adenocarcinoma - drug therapy Adult Aged Animals Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carcinoma, Adenosquamous - blood Carcinoma, Adenosquamous - drug therapy Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - drug therapy Case-Control Studies cervical cancer Chemotherapy circulating nucleosomes Cisplatin - therapeutic use Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives DNA, Neoplasm - blood DNA, Viral - blood ELISA Enzyme-Linked Immunosorbent Assay Female HeLa Cells Humans In Vitro Techniques Medical sciences Mice Mice, Nude Middle Aged neoadjuvant chemotherapy Neoadjuvant Therapy Neoplastic Cells, Circulating - metabolism Nucleosomes - metabolism Organoplatinum Compounds - administration & dosage Paclitaxel - administration & dosage Papillomaviridae - pathogenicity Papillomavirus Infections - blood Papillomavirus Infections - drug therapy Pharmacology. Drug treatments Prognosis Rats Rats, Wistar Tumor Virus Infections - blood Tumor Virus Infections - drug therapy Uterine Cervical Neoplasms - blood Uterine Cervical Neoplasms - drug therapy Antineoplastic agent Gemcitabine Rat Uterine cervix Oxaliplatin Serum Pyrimidine nucleoside Non small cell carcinoma Platinum II Complexes Drug combination Treatment efficiency Nucleosome Rodentia Malignant tumor In vitro Cisplatin Female genital diseases In vivo Vertebrata Alkylating agent Chemotherapy Mammalia Treatment Antimetabolic Mouse Animal Fluorine Organic compounds Uterine cervix diseases
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