Successful salvage chemotherapy with amrubicin for invasive thymoma associated with myasthenia gravis

Anthracycline-based regimens with cisplatin have been commonly used for inoperable and relapsed thymoma. However, little information is available regarding the usefulness of salvage chemotherapy. Here, we describe a case of invasive thymoma associated with myasthenia gravis that showed a marked resp...

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Bibliographic Details
Published in:	Japanese journal of clinical oncology Vol. 44; no. 11; pp. 1120 - 1122
Main Authors:	Fukushima, Toshirou, Gomi, Daisuke, Kobayashi, Takashi, Sekiguchi, Nodoka, Sakamoto, Akiyuki, Sasaki, Shigeru, Koizumi, Tomonobu
Format:	Journal Article
Language:	English
Published:	England 01-11-2014
Subjects:	Adult Anthracyclines - therapeutic use Antibiotics, Antineoplastic - therapeutic use Female Humans Myasthenia Gravis - complications Salvage Therapy - methods Thymoma - diagnostic imaging Thymoma - drug therapy Thymoma - etiology Thymoma - pathology Thymus Neoplasms - diagnostic imaging Thymus Neoplasms - drug therapy Thymus Neoplasms - etiology Thymus Neoplasms - pathology Tomography, X-Ray Computed Treatment Outcome anthracycline chemotherapy topoisomerase II inhibitor relapsed thymoma
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Summary:	Anthracycline-based regimens with cisplatin have been commonly used for inoperable and relapsed thymoma. However, little information is available regarding the usefulness of salvage chemotherapy. Here, we describe a case of invasive thymoma associated with myasthenia gravis that showed a marked response to third-line chemotherapy, with single-agent amrubicin, a synthetic anthracycline analog and potent deoxyribonucleic acid topoisomerase II inhibitor. Amrubicin appears to have significant activity against invasive thymoma.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0368-2811 1465-3621
DOI:	10.1093/jjco/hyu136