Myelomodulatory treatments augment the therapeutic benefit of oncolytic viroimmunotherapy in murine models of malignant peripheral nerve sheath tumors

Malignant peripheral nerve sheath tumors (MPNST) pose a significant therapeutic challenge due to high recurrence rates after surgical resection and a largely ineffective response to traditional chemotherapy. An alternative treatment strategy is oncolytic viroimmunotherapy, which can elicit a durable...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 15; p. 1384623
Main Authors:	Paudel, Siddhi N, Hutzen, Brian J, Miller, Katherine E, Garfinkle, Elizabeth A R, Chen, Chun-Yu, Wang, Pin-Yi, Glaspell, Andrea M, Currier, Mark A, Ringwalt, Emily M, Boon, Louis, Mardis, Elaine R, Cairo, Mitchell S, Ratner, Nancy, Dodd, Rebecca D, Cassady, Kevin A, Cripe, Timothy P
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 25-06-2024
Subjects:	Aminopyridines Animals Cell Line, Tumor Combined Modality Therapy Disease Models, Animal Female Humans Immunology immunotherapy Immunotherapy - methods macrophage targeting malignant peripheral nerve sheath tumors Mice Mice, Inbred C57BL Nerve Sheath Neoplasms - genetics Nerve Sheath Neoplasms - immunology Nerve Sheath Neoplasms - therapy oncolytic virotherapy Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Oncolytic Viruses - immunology Pyrroles trabectedin tumor microenvironment Tumor Microenvironment - immunology macrophage targeting trabectedin immunotherapy oncolytic virotherapy tumor microenvironment malignant peripheral nerve sheath tumors pexidartinib T-VEC
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