Regional variations in psoriatic arthritis: Insights from a nationwide multicenter analysis in Türkiye

• Published in: Archives of rheumatology Vol. 39; no. 3; pp. 339 - 349
• Main Authors: Kilic, Erkan, Kilic, Gamze, Tekeoglu, Ibrahim, Sargin, Betul, Kasman, Sevtap Acer, Alkan, Hakan, Sahin, Nilay, Cengiz, Gizem, Cuzdan, Nihan, Gezer, Ilknur Albayrak, Keskin, Dilek, Mulkoglu, Cevriye, Resorlu, Hatice, Sunar, Ismihan, Bal, Ajda, Duruoz, Mehmet Tuncay, Kucukakkas, Okan, Yurdakul, Ozan Volkan, Melikoglu, Meltem Alkan, Aydin, Yildiray, Ayhan, Fikriye Figen, Bodur, Hatice, Calis, Mustafa, Capkin, Erhan, Devrimsel, Gul, Orhan, Kevser, Hizmetli, Sami, Kamanli, Ayhan, Keskin, Yasar, Ecesoy, Hilal, Kutluk, Oznur, Sen, Nesrin, Sendur, Omer Faruk, Tolu, Sena, Toprak, Murat, Tuncer, Tiraje, Nas, Kemal
• Format: Journal Article
• Language: English
• Published: Istanbul Turkish League Against Rheumatism 01-09-2024; Prof Sebnem Ataman, President Turkish League Against Rheumatism
• Subjects: Age; Analysis; Black Sea; Body mass index; Chronic illnesses; Comorbidity; Cross-sectional studies; Diseases; Family medical history; Fibromyalgia; Geography; Inflammatory bowel disease; Medical care; Medical referrals; Medical research; Medicine, Experimental; Original; Patient compliance; Patients; Psoriasis; Psoriatic arthritis; Quality management; Quality of life; Questionnaires; Regional differences; Rheumatic diseases; Skin; Systematic review; Black Sea; Middle East; Anatolia; Turkey; Asia; Europe; North America; Latin America
• ISSN: 2148-5046; 1309-0291; 2618-6500; 1309-0283
• DOI: 10.46497/ArchRheumatol.2024.10591

Objectives: The study aimed to investigate and compare clinical features, disease activity, and the overall disease burden among psoriatic arthritis (PsA) patients across seven distinct geographic regions in Turkiye. Patients and methods: A multicenter cross-sectional study involving 1,134 PsA patients from 25 referral centers across seven regions was conducted. Demographic and clinical characteristics, comorbidities, joint involvement, extra-articular manifestations, and disease activity measures were evaluated across regions. Results: A total of 1134 PsA patients from seven different geographic regions in Turkiye participated in this study. The highest number of participants was from the Marmara region (n=409), with subsequent representation from Central Anatolia (n=370), Aegean (n=139), Mediterranean (n=60), Black Sea (n=60), Eastern Anatolia (n=60), and Southeastern Anatolia (n=36) regions. There were significant variations in demographic profile, including age, body mass index, age of disease onset, educational status, comorbidities, and family history of both psoriasis and PsA. Clinical features, such as enthesitis, dactylitis, uveitis, and joint involvement, demonstrated significant variation across regions. Additionally, disease activity measures, including pain, patient and physician global assessments, acute phase reactants, disease activity indices, quality of life, and functional status, displayed considerable regional differences. Conclusion: This nationwide study revealed substantial regional diversity in demographic data, clinical characteristics, disease activity, and quality of life among PsA patients in Turkiye. These findings stress the need to customize treatment approaches to address regional needs and to conduct further research to uncover reasons for disparities. It is crucial to enhance region-specific approaches to improve patient care and outcomes for PsA. Keywords: Arthritis, differences, geographic locations, psoriatic, regional, spondyloarthritis.