The novel chimeric multi-agonist peptide (GEP44) reduces energy intake and body weight in male and female diet-induced obese mice in a glucagon-like peptide-1 receptor-dependent manner

We recently reported that a novel chimeric peptide (GEP44) targeting both the glucagon-like peptide-1 receptor (GLP-1R) and neuropeptide Y1- and Y2 receptor (Y1R and Y2R) reduced energy intake and body weight (BW) in diet-induced obese (DIO) rats. We hypothesized that GEP44 reduces energy intake and...

Full description

Saved in:

Bibliographic Details
Published in:	Frontiers in endocrinology (Lausanne) Vol. 15; p. 1432928
Main Authors:	Blevins, James E, Honeycutt, Mackenzie K, Slattery, Jared D, Goldberg, Matvey, Rambousek, June R, Tsui, Edison, Dodson, Andrew D, Shelton, Kyra A, Salemeh, Therese S, Elfers, Clinton T, Chichura, Kylie S, Ashlaw, Emily F, Zraika, Sakeneh, Doyle, Robert P, Roth, Christian L
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 22-07-2024
Subjects:	Animals Body Weight - drug effects Diet, High-Fat - adverse effects Endocrinology Energy Intake - drug effects Female GLP-1 Glucagon-Like Peptide-1 Receptor - agonists Glucagon-Like Peptide-1 Receptor - metabolism IBAT IWAT Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Obese multi-agonist obesity Obesity - drug therapy Obesity - metabolism PYY PYY GLP-1 IWAT multi-agonist IBAT obesity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!