Histopathological Examination of a Symptomatic Carotid Web: A Case Report

Carotid webs cause ischemic stroke in young people and are associated with a high rate of stroke recurrence. Histopathological examination is crucial for clarifying the pathogenesis and mechanisms underlying the occurrence of carotid webs, although the mechanisms generally remain unclear. Here, we r...

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Published in:	NMC Case Report Journal Vol. 11; pp. 69 - 74
Main Authors:	ARAI, Yukika, CHO, Junshi, FUJINO, Asuka, TAIRA, Naoki, KUNIEDA, Junko, KOIKE, Morio
Format:	Journal Article
Language:	English
Published:	Japan The Japan Neurosurgical Society 31-12-2024
Subjects:	carotid endarterectomy carotid web Case Report cerebral ischemia stroke stroke in young adults carotid endarterectomy carotid web stroke in young adults stroke cerebral ischemia
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Abstract	Carotid webs cause ischemic stroke in young people and are associated with a high rate of stroke recurrence. Histopathological examination is crucial for clarifying the pathogenesis and mechanisms underlying the occurrence of carotid webs, although the mechanisms generally remain unclear. Here, we report a case of a symptomatic carotid web in a woman in her 50s who had a medical history of two ischemic strokes. She was diagnosed with a right carotid web and underwent carotid endarterectomy 18 days after the second stroke. Histopathological examination clearly revealed several phases of intimal hyperplasia. Furthermore, a thrombus attached to the carotid web showed invasion by fibroblasts and capillaries, and organization had begun. We presume that after the appearance of the carotid web, the thrombus formed by stagnant flow and became organized, causing the carotid web to grow and change in shape.
AbstractList	Carotid webs cause ischemic stroke in young people and are associated with a high rate of stroke recurrence. Histopathological examination is crucial for clarifying the pathogenesis and mechanisms underlying the occurrence of carotid webs, although the mechanisms generally remain unclear. Here, we report a case of a symptomatic carotid web in a woman in her 50s who had a medical history of two ischemic strokes. She was diagnosed with a right carotid web and underwent carotid endarterectomy 18 days after the second stroke. Histopathological examination clearly revealed several phases of intimal hyperplasia. Furthermore, a thrombus attached to the carotid web showed invasion by fibroblasts and capillaries, and organization had begun. We presume that after the appearance of the carotid web, the thrombus formed by stagnant flow and became organized, causing the carotid web to grow and change in shape.
ArticleNumber	2023-0181
Author	TAIRA, Naoki CHO, Junshi KUNIEDA, Junko KOIKE, Morio FUJINO, Asuka ARAI, Yukika
Author_xml	– sequence: 1 fullname: ARAI, Yukika organization: Department of Neurosurgery, Shuuwa General Hospital – sequence: 2 fullname: CHO, Junshi organization: Department of Neurosurgery, Shuuwa General Hospital – sequence: 3 fullname: FUJINO, Asuka organization: Department of Neurosurgery, Shuuwa General Hospital – sequence: 4 fullname: TAIRA, Naoki organization: Department of Neurosurgery, Shuuwa General Hospital – sequence: 5 fullname: KUNIEDA, Junko organization: Department of Pathology, Tokyo Medical and Dental University – sequence: 6 fullname: KOIKE, Morio organization: Department of Pathology, Shuuwa General Hospital
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/38590927$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1007/BF00878882 10.1001/jamaneurol.2018.3366 10.1159/000489710 10.3171/2018.7.JNS181579 10.1002/ana.26508 10.1016/S0890-5096(06)61448-9 10.2176/nmc.oa.2014-0049 10.1097/00000658-196803000-00021 10.2176/nmc.oa.2016-0036 10.1016/j.wneu.2016.11.050 10.1177/03000605211059929 10.3171/2020.5.JNS201107 10.3174/ajnr.A4431 10.2176/nmc.oa.2020-0154 10.1161/STROKEAHA.117.019020 10.1016/j.carpath.2023.107544 10.1016/j.jns.2021.117550 10.1161/STROKEAHA.114.007313 10.1161/STROKEAHA.118.021907 10.1002/ana.410060120 10.1161/STROKEAHA.116.013918 10.2176/nmc.tn.2014-0202
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Keywords	carotid endarterectomy carotid web stroke in young adults stroke cerebral ischemia
Language	English
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Notes	e-mail: yuk1ka127@gmail.com Department of Neurosurgery, Shuuwa General Hospital, 1200 Tanihara-shinden, Kasukabe, Saitama 344-0035, Japan. Corresponding author: Yukika Arai, MD.
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SubjectTerms	carotid endarterectomy carotid web Case Report cerebral ischemia stroke stroke in young adults
Title	Histopathological Examination of a Symptomatic Carotid Web: A Case Report
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