Nanoparticles Targeting the Molecular Pathways of Heart Remodeling and Regeneration

Cardiovascular diseases are the main cause of death worldwide, a trend that will continue to grow over the next decade. The heart consists of a complex cellular network based mainly on cardiomyocytes, but also on endothelial cells, smooth muscle cells, fibroblasts, and pericytes, which closely commu...

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Bibliographic Details
Published in:	Pharmaceutics Vol. 14; no. 4; p. 711
Main Authors:	Gonciar, Diana, Mocan, Teodora, Agoston-Coldea, Lucia
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 26-03-2022 MDPI
Subjects:	cardiomyocytes Cardiovascular disease Contrast agents Drugs Heart attacks Iodine Lipids Magnetic resonance imaging Metabolism Nanoparticles Polyamines Polyethylene glycol regeneration remodeling Review Tomography cardiomyocytes remodeling nanoparticles regeneration
Online Access:	Get full text
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Summary:	Cardiovascular diseases are the main cause of death worldwide, a trend that will continue to grow over the next decade. The heart consists of a complex cellular network based mainly on cardiomyocytes, but also on endothelial cells, smooth muscle cells, fibroblasts, and pericytes, which closely communicate through paracrine factors and direct contact. These interactions serve as valuable targets in understanding the phenomenon of heart remodeling and regeneration. The advances in nanomedicine in the controlled delivery of active pharmacological agents are remarkable and may provide substantial contribution to the treatment of heart diseases. This review aims to summarize the main mechanisms involved in cardiac remodeling and regeneration and how they have been applied in nanomedicine.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1999-4923 1999-4923
DOI:	10.3390/pharmaceutics14040711