Differences between the metabolic profiles of decompensated and compensated cirrhosis patients with Hepatitis B virus infections under high-performance liquid chromatography-mass spectrometry
To improve the grading and staging of liver cirrhosis among patients with HBV infection noninvasively, a high-performance liquid chromatography with mass spectrometry metabolomics method was used to investigate the potential metabolic biomarkers in the serum of patients with different degrees of hep...
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| Published in: | Metabolomics Vol. 8; no. 5; pp. 845 - 853 |
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| Main Authors: | , , , , , , , , , , , |
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| Abstract | To improve the grading and staging of liver cirrhosis among patients with HBV infection noninvasively, a high-performance liquid chromatography with mass spectrometry metabolomics method was used to investigate the potential metabolic biomarkers in the serum of patients with different degrees of hepatic cirrhosis. The results demonstrate that lysophosphatidyl choline (LPC) from positive electrospray ionization (ESI) mode, and fatty acids and bile acids from negative ESI mode play important roles in distinguishing decompensated from compensated cirrhosis. A total of 21 differential metabolites were found from the two groups of patients. LPCs, fatty acids, and taurocholic acid (TCA) 3-sulfate decreased in patients with decompensated cirrhosis, whereas other bile acids increased significantly. The levels of TCA 3-sulfate, LPC 16:0, and LPC 18:0 were significantly correlated with the stages of the decompensated cirrhosis, and they may serve as potential biomarkers for the stage assessment of liver cirrhosis in patients with HBV infections. |
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| AbstractList | To improve the grading and staging of liver cirrhosis among patients with HBV infection noninvasively, a high-performance liquid chromatography with mass spectrometry metabolomics method was used to investigate the potential metabolic biomarkers in the serum of patients with different degrees of hepatic cirrhosis. The results demonstrate that lysophosphatidyl choline (LPC) from positive electrospray ionization (ESI) mode, and fatty acids and bile acids from negative ESI mode play important roles in distinguishing decompensated from compensated cirrhosis. A total of 21 differential metabolites were found from the two groups of patients. LPCs, fatty acids, and taurocholic acid (TCA) 3-sulfate decreased in patients with decompensated cirrhosis, whereas other bile acids increased significantly. The levels of TCA 3-sulfate, LPC 16:0, and LPC 18:0 were significantly correlated with the stages of the decompensated cirrhosis, and they may serve as potential biomarkers for the stage assessment of liver cirrhosis in patients with HBV infections. To improve the grading and staging of liver cirrhosis among patients with HBV infection noninvasively, a high-performance liquid chromatography with mass spectrometry metabolomics method was used to investigate the potential metabolic biomarkers in the serum of patients with different degrees of hepatic cirrhosis. The results demonstrate that lysophosphatidyl choline (LPC) from positive electrospray ionization (ESI) mode, and fatty acids and bile acids from negative ESI mode play important roles in distinguishing decompensated from compensated cirrhosis. A total of 21 differential metabolites were found from the two groups of patients. LPCs, fatty acids, and taurocholic acid (TCA) 3-sulfate decreased in patients with decompensated cirrhosis, whereas other bile acids increased significantly. The levels of TCA 3-sulfate, LPC 16:0, and LPC 18:0 were significantly correlated with the stages of the decompensated cirrhosis, and they may serve as potential biomarkers for the stage assessment of liver cirrhosis in patients with HBV infections.[PUBLICATION ABSTRACT] |
| Author | Chen, Nan Zheng, Shufa Wang, Feiling Xu, Zhiliang Kong, Hongwei Chen, Zhenjing Chen, Yu Li, Lanjuan Zhou, Lina Chen, Jing Dong, Yuejiao Xu, Guowang |
| Author_xml | – sequence: 1 givenname: Yu surname: Chen fullname: Chen, Yu organization: Center of Clinical Laboratory, First Affiliated Hospital, College of Medicine, Zhejiang University, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University – sequence: 2 givenname: Zhiliang surname: Xu fullname: Xu, Zhiliang organization: CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 3 givenname: Hongwei surname: Kong fullname: Kong, Hongwei email: konghw@dicp.ac.cn organization: CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 4 givenname: Nan surname: Chen fullname: Chen, Nan organization: Center of Clinical Laboratory, First Affiliated Hospital, College of Medicine, Zhejiang University – sequence: 5 givenname: Jing surname: Chen fullname: Chen, Jing organization: CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 6 givenname: Lina surname: Zhou fullname: Zhou, Lina organization: CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 7 givenname: Feiling surname: Wang fullname: Wang, Feiling organization: Wenzhou Medical College – sequence: 8 givenname: Yuejiao surname: Dong fullname: Dong, Yuejiao organization: Center of Clinical Laboratory, First Affiliated Hospital, College of Medicine, Zhejiang University – sequence: 9 givenname: Shufa surname: Zheng fullname: Zheng, Shufa organization: Center of Clinical Laboratory, First Affiliated Hospital, College of Medicine, Zhejiang University – sequence: 10 givenname: Zhenjing surname: Chen fullname: Chen, Zhenjing organization: Center of Clinical Laboratory, First Affiliated Hospital, College of Medicine, Zhejiang University – sequence: 11 givenname: Guowang surname: Xu fullname: Xu, Guowang organization: CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 12 givenname: Lanjuan surname: Li fullname: Li, Lanjuan email: ljli@zju.edu.cn organization: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University |
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| Cites_doi | 10.1016/S0140-6736(07)60723-5 10.1002/hep.22742 10.3945/jn.108.101782 10.1021/ac702089h 10.1016/j.aca.2011.02.038 10.1053/jhep.2001.20534 10.1111/j.1349-7006.2009.01086.x 10.1021/pr070183p 10.1021/pr1002388 10.1016/j.bbrc.2009.12.119 10.1021/pr200265z 10.1136/bmj.319.7208.471 10.1515/CCLM.2009.083 10.1016/j.jhep.2008.04.023 10.1073/pnas.91.15.6919 10.1021/pr050364w 10.1039/b820224a 10.1111/j.1530-0277.1996.tb01730.x 10.1159/000113756 10.1203/00006450-199803000-00009 10.1093/clinchem/37.12.2102 |
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| Keywords | HPLC–MS Compensated liver cirrhosis Metabolomics Child-turcotte-pugh scoring Decompensated liver cirrhosis Hepatitis B |
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| SubjectTerms | Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Developmental Biology Hepatitis B virus Life Sciences Molecular Medicine Original Article |
| Title | Differences between the metabolic profiles of decompensated and compensated cirrhosis patients with Hepatitis B virus infections under high-performance liquid chromatography-mass spectrometry |
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