Corticotropin-releasing hormone receptors

Corticotropin-releasing hormone receptors

Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-prote...

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Bibliographic Details
Published in:Biochemical Society transactions Vol. 30; no. 4; p. 428
Main Authors: Hillhouse, E W, Randeva, H, Ladds, G, Grammatopoulos, D
Format: Journal Article
Language:English
Published: England 01-08-2002
Subjects:
Animals
GTP-Binding Proteins - physiology
Humans
Receptors, Corticotropin-Releasing Hormone - genetics
Receptors, Corticotropin-Releasing Hormone - physiology
Recombinant Proteins - metabolism
Signal Transduction
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Summary:Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural and functional characteristics of the family of CRH-like peptides and their receptors.
ISSN:0300-5127
DOI:10.1042/bst0300428