Angiotensin I and II Stimulate Cell Invasion of SARS-CoV-2: Potential Mechanism via Inhibition of ACE2 Arm of RAS

Angiotensin-converting enzyme 2 (ACE2), one of the key enzymes of the renin-angiotensin system (RAS), plays an important role in SARS-CoV-2 infection by functioning as a virus receptor. Angiotensin peptides Ang I and Ang II, the substrates of ACE2, can modulate the binding of SARS-CoV-2 Spike protei...

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Bibliographic Details
Published in:	Physiological research Vol. 73; no. 1; pp. 27 - 35
Main Authors:	Zorad, S, Skrabanova, M, Zilkova, M, Cente, M, Turic Csokova, N, Kovacech, B, Cizkova, D, Filipcik, P
Format:	Journal Article
Language:	English
Published:	Czech Republic Institute of Physiology 2024 Institute of Physiology of the Czech Academy of Sciences
Subjects:	ACE2 Angiotensin Angiotensin I Angiotensin I - metabolism Angiotensin I - pharmacology Angiotensin II Angiotensin II - metabolism Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - metabolism Angiotensin-Converting Enzyme Inhibitors Antibodies Comorbidity COVID-19 Endocrine system Enzymes Humans Infections Infectivity Metabolism Metabolites Penicillin Peptides Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - metabolism Proteins Renin Renin-Angiotensin System SARS-CoV-2 - metabolism Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus Spike protein Viruses
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