Mitral Valve Prolapse: Evaluation With ECG-Gated Cardiac CT Angiography

• Published in: American journal of roentgenology (1976) Vol. 194; no. 3; pp. 579 - 584
• Main Authors: Shah, Rajnil G, Novaro, Gian M, Blandon, Rodolfo J, Wilkinson, Lana, Asher, Craig R, Kirsch, Jacobo
• Format: Journal Article
• Language: English
• Published: Reston, VA Am Roentgen Ray Soc 01-03-2010; American Roentgen Ray Society
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Cardiovascular system; Contrast Media; Coronary Angiography - methods; Echocardiography; Electrocardiography; Feasibility Studies; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Mitral Valve Prolapse - diagnostic imaging; Predictive Value of Tests; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiographic Image Interpretation, Computer-Assisted; Retrospective Studies; Sensitivity and Specificity; Tomography, X-Ray Computed; Triiodobenzoic Acids; Heart; Electrodiagnosis; Mitral valve prolapse; Angiography; Radiodiagnosis; Electrocardiography; Medical imagery; Computerized axial tomography; Angiocomputed tomography; Gating
• ISSN: 0361-803X; 1546-3141
• DOI: 10.2214/AJR.09.2545

The purpose of our study was to evaluate the feasibility of detecting mitral valve prolapse with ECG-gated 64-MDCT angiography in comparison with the reference standard, transthoracic echocardiography.
The charts of patients consecutively referred for clinically indicated 64-MDCT angiography were reviewed. The study cohort consisted of patients who had undergone transthoracic echocardiography. Two experienced radiologists performed blinded consensus review of the MDCT angiograms of 20 patients, and the findings were compared with those of transthoracic echocardiography, which was the reference standard.
With the findings on each anterior and posterior leaflet as separate data points, sensitivity was calculated to be 69.2-84.6% and specificity, 100%. The positive and negative predictive values were estimated to be 100% and 87.0-93.1%.
ECG-gated cardiac 64-MDCT angiography can be used reliably to detect mitral valve prolapse.