Mast cells. Receptors, secretagogues, and signaling

Mast cells (MC) are a major cell type involved in a number of pathological processes, from local cutaneous reactions to systemic inflammatory responses, which if not controlled, could be life threatening. In these situations, MC are believed to be the initial effector cells. They express various rec...

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Bibliographic Details
Published in:	Clinical reviews in allergy & immunology Vol. 22; no. 2; pp. 119 - 148
Main Authors:	Sharma, Bhavya B, Apgar, John R, Liu, Fu-Tong
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-04-2002
Subjects:	Animals Humans Immunologic Factors - physiology Inflammation Mediators - physiology Mast Cells - physiology Receptors, IgE - physiology Signal Transduction - physiology
Online Access:	Get full text
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Summary:	Mast cells (MC) are a major cell type involved in a number of pathological processes, from local cutaneous reactions to systemic inflammatory responses, which if not controlled, could be life threatening. In these situations, MC are believed to be the initial effector cells. They express various receptors, which, upon crosslinking or ligand binding, lead to the initiation of signaling events resulting in degranulation and/or synthesis and production of eicosanoids and cytokines. This is followed by events mediated by other cells types, including eosinophils, which culminate in the manifestation of the allergic disease.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	1080-0549 1080-0549 1559-0267
DOI:	10.1385/CRIAI:22:2:119