Enhanced tissue regeneration using an nano- bioactive scaffold- A novel perspective
The present study, COLL: AV: GPO bioactive scaffold prepared from collagen (COLL), Aloe vera (AV) and graphene oxide (GPO) for wound healing application. Bioactive scaffolds were examined by Fourier Transform Infrared Spectroscopy (FT-IR), Thermogravimetry Analysis (TGA) to understand the intermolec...
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| Published in: | Materials chemistry and physics Vol. 240; p. 122303 |
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| Format: | Journal Article |
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| Abstract | The present study, COLL: AV: GPO bioactive scaffold prepared from collagen (COLL), Aloe vera (AV) and graphene oxide (GPO) for wound healing application. Bioactive scaffolds were examined by Fourier Transform Infrared Spectroscopy (FT-IR), Thermogravimetry Analysis (TGA) to understand the intermolecular interaction and their influence on the thermal property of the composite. Scanning Electron Microscope (SEM) image of the bioactive scaffold showed porous and smooth surface. Atomic Force Microscopy (AFM) observed fibrils with intermittent banding patterns. Bioactive scaffold possessed tensile strength (MPa), elongation at break (%), and water absorption properties (%). Bioactive scaffold exhibited good anti-bacterial activity against E.coli and S.aureus. MTT assay on the composites showed enhanced cell growth of human keratinocyte cell line (HaCaT) without exhibiting any toxicity. A higher rate of cell growth present in the COLL: AV: GPO bioactive scaffold compared to the other samples (COLL and COLL: AV) was observed. Acceleration of wound healing in COLL: AV: GPO bioactive scaffold treated rats were significantly in the in vivo experiments. These results suggested that the COLL: AV: GPO bioactive scaffold could be promising materials from wound healing applications.
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•BS was successfully prepared from COLL, AV and GPO.•BS had necessary strength for wound dressing material production.•BS had necessary promising bio scaffold for wound healing application.•Conversion of leather waste to value added products. |
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| AbstractList | The present study, COLL: AV: GPO bioactive scaffold prepared from collagen (COLL), Aloe vera (AV) and graphene oxide (GPO) for wound healing application. Bioactive scaffolds were examined by Fourier Transform Infrared Spectroscopy (FT-IR), Thermogravimetry Analysis (TGA) to understand the intermolecular interaction and their influence on the thermal property of the composite. Scanning Electron Microscope (SEM) image of the bioactive scaffold showed porous and smooth surface. Atomic Force Microscopy (AFM) observed fibrils with intermittent banding patterns. Bioactive scaffold possessed tensile strength (MPa), elongation at break (%), and water absorption properties (%). Bioactive scaffold exhibited good anti-bacterial activity against E.coli and S.aureus. MTT assay on the composites showed enhanced cell growth of human keratinocyte cell line (HaCaT) without exhibiting any toxicity. A higher rate of cell growth present in the COLL: AV: GPO bioactive scaffold compared to the other samples (COLL and COLL: AV) was observed. Acceleration of wound healing in COLL: AV: GPO bioactive scaffold treated rats were significantly in the in vivo experiments. These results suggested that the COLL: AV: GPO bioactive scaffold could be promising materials from wound healing applications. The present study, COLL: AV: GPO bioactive scaffold prepared from collagen (COLL), Aloe vera (AV) and graphene oxide (GPO) for wound healing application. Bioactive scaffolds were examined by Fourier Transform Infrared Spectroscopy (FT-IR), Thermogravimetry Analysis (TGA) to understand the intermolecular interaction and their influence on the thermal property of the composite. Scanning Electron Microscope (SEM) image of the bioactive scaffold showed porous and smooth surface. Atomic Force Microscopy (AFM) observed fibrils with intermittent banding patterns. Bioactive scaffold possessed tensile strength (MPa), elongation at break (%), and water absorption properties (%). Bioactive scaffold exhibited good anti-bacterial activity against E.coli and S.aureus. MTT assay on the composites showed enhanced cell growth of human keratinocyte cell line (HaCaT) without exhibiting any toxicity. A higher rate of cell growth present in the COLL: AV: GPO bioactive scaffold compared to the other samples (COLL and COLL: AV) was observed. Acceleration of wound healing in COLL: AV: GPO bioactive scaffold treated rats were significantly in the in vivo experiments. These results suggested that the COLL: AV: GPO bioactive scaffold could be promising materials from wound healing applications. [Display omitted] •BS was successfully prepared from COLL, AV and GPO.•BS had necessary strength for wound dressing material production.•BS had necessary promising bio scaffold for wound healing application.•Conversion of leather waste to value added products. |
| ArticleNumber | 122303 |
| Author | Rethinam, Senthil Aruni, A. Wilson Alagumuthu, Tamilselvi Basaran, Bahri Vijayan, Sumathi Ramamoorthy, Rajalakshmi |
| Author_xml | – sequence: 1 givenname: Senthil orcidid: 0000-0002-3187-5673 surname: Rethinam fullname: Rethinam, Senthil email: senthilbiop@gmail.com organization: Department of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, 600 199, Tamilnadu, India – sequence: 2 givenname: Sumathi surname: Vijayan fullname: Vijayan, Sumathi organization: School of Electrical and Electronics Engineering, VIT University, Chennai, 600 127, Tamilnadu, India – sequence: 3 givenname: A. Wilson surname: Aruni fullname: Aruni, A. Wilson organization: School of Bio & Chemical Engineering, Sathyabama Institute of Science and Technology, Chennai, 600 119, Tamilnadu, India – sequence: 4 givenname: Bahri surname: Basaran fullname: Basaran, Bahri organization: School of Natural and Applied Science, Ege University, 35100, Bornova, izmir, Turkey – sequence: 5 givenname: Tamilselvi surname: Alagumuthu fullname: Alagumuthu, Tamilselvi organization: CHORD, Central Leather Research Institute-CSIR, Chennai, 600020, Tamilnadu, India – sequence: 6 givenname: Rajalakshmi surname: Ramamoorthy fullname: Ramamoorthy, Rajalakshmi organization: Department of Textile Technology, Anna University, Chennai, 600 025, Tamilnadu, India |
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| Cites_doi | 10.4103/0972-124X.118333 10.1016/j.mattod.2013.09.004 10.1016/0925-4439(94)00056-V 10.1016/j.jddst.2018.08.010 10.1016/0141-8130(91)90058-3 10.1016/j.msec.2015.07.047 10.3390/ijms18010096 10.1016/S0305-4179(98)00087-4 10.1016/j.colsurfb.2014.06.018 10.1271/bbb.60659 10.1016/0167-4838(88)90107-0 10.1067/msg.2001.111167 10.1080/19336918.2015.1005469 10.1021/ja01539a017 10.5301/ijao.5000531 10.1021/nn505700x 10.1016/0167-7799(93)90098-T 10.1021/jf001036d 10.1177/0391398818775949 10.1098/rsif.2009.0403 10.1016/j.foodchem.2008.06.020 10.1371/journal.pone.0164799 10.1111/j.1365-2133.2010.09804.x 10.1021/am401637c |
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Food Chem. doi: 10.1021/jf001036d contributor: fullname: Pugh – volume: 41 start-page: 1 year: 2018 ident: 10.1016/j.matchemphys.2019.122303_bib21 article-title: PVA/Collagen nanofiber scaffold hybridized by graphine oxide by accelerated wound healing publication-title: Int. J. Artif. Organs doi: 10.1177/0391398818775949 contributor: fullname: Senthil – volume: 7 start-page: 229 year: 2010 ident: 10.1016/j.matchemphys.2019.122303_bib25 article-title: A review of tissue-engineered skin bioconstructs available for skin reconstruction publication-title: J. R. Soc. Interface doi: 10.1098/rsif.2009.0403 contributor: fullname: Shevchenko – volume: 112 start-page: 702 year: 2009 ident: 10.1016/j.matchemphys.2019.122303_bib11 article-title: Properties of collagen from skin, scale and bones of carb (cyprinus) publication-title: Food Chem. doi: 10.1016/j.foodchem.2008.06.020 contributor: fullname: Duan – volume: 11 start-page: 1 year: 2016 ident: 10.1016/j.matchemphys.2019.122303_bib23 article-title: Beneficial effects of the genus aloe on wound healing, cell proliferation, and differentiation of epidermal keratinocytes publication-title: PLoS One doi: 10.1371/journal.pone.0164799 contributor: fullname: Moriyama – volume: 163 start-page: 257 year: 2010 ident: 10.1016/j.matchemphys.2019.122303_bib4 article-title: Oxygen in acute and chronic wound healing publication-title: Br. J. Dermatol. doi: 10.1111/j.1365-2133.2010.09804.x contributor: fullname: Schreml – volume: 14 start-page: 7291 year: 2013 ident: 10.1016/j.matchemphys.2019.122303_bib20 article-title: Preparation and characterization of aloe vera blended collagen-chitosan composite scaffold for tissue engineering applications publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/am401637c contributor: fullname: Jithendra |
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| Snippet | The present study, COLL: AV: GPO bioactive scaffold prepared from collagen (COLL), Aloe vera (AV) and graphene oxide (GPO) for wound healing application.... |
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| SubjectTerms | Acceleration Aloevera Atomic force microscopes Atomic force microscopy Bioactive scaffold Biocompatibility Biological activity Cell growth Collagen E coli Elongation Fourier transforms Graphene Graphene oxide Infrared analysis Infrared spectroscopy Regeneration Scaffolds Tensile strength Thermodynamic properties Thermogravimetry Tissue engineering Toxicity Water absorption Wound dressing Wound healing |
| Title | Enhanced tissue regeneration using an nano- bioactive scaffold- A novel perspective |
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