Prognostic factors in well-differentiated follicular-derived carcinoma and medullary thyroid carcinoma

• Published in: Thyroid (New York, N.Y.) Vol. 11; no. 7; p. 637
• Main Authors: Baloch, Z W, LiVolsi, V A
• Format: Journal Article
• Language: English
• Published: United States 01-07-2001
• Subjects: Adenoma - diagnosis; Carcinoma, Medullary - diagnosis; Humans; Prognosis; Thyroid Neoplasms - diagnosis
• ISSN: 1050-7256
• DOI: 10.1089/105072501750362709

This paper reviews both clinicopathologic and biological factors in differentiated thyroid carcinoma of follicular and C-cell derivation. The value of specific histological parameters including tumor subtypes, vascular invasion as predictors of prognosis in these tumors is discussed and the pertinent literature reviewed. The utility of ploidy analysis and immunohistochemical assessment of hormonal and tumor markers are described. Current information on biological and molecular markers that may be helpful in predicting behavior is discussed. The commonly used staging systems for thyroid cancer are briefly described.