Impact of bound ssRNA length on allostery in the Dengue Virus NS3 helicase

Abstract The presence of ATP is known to stimulate helicase activity of the Dengue Virus Non-structural protein 3 helicase (NS3h), and the presence of RNA stimulates NS3h ATPase activity, however this coupling is still mechanistically unclear. Here we use atomistic models and molecular dynamics simu...

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Bibliographic Details

Published in:	Nucleic acids research Vol. 51; no. 20; pp. 11213 - 11224
Main Authors:	Amrein, Fernando, Sarto, Carolina, Cababie, Leila A, Gonzalez Flecha, F Luis, Kaufman, Sergio B, Arrar, Mehrnoosh
Format:	Journal Article
Language:	English
Published:	Oxford University Press 10-11-2023
Subjects:	Nucleic Acid Enzymes
Online Access:	Get full text
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