New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn

Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (1- 2) and four known (3- 6) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evalu...

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Bibliographic Details
Published in:	Planta medica Vol. 77; no. 14; p. 1648
Main Authors:	Lang, Karen L, da Rosa Guimarães, Tatiana, Rocha Machado, Vanessa, Zimmermann, Lara A, Silva, Izabella T, Teixeira, Marina R, Durán, Fernando J, Palermo, Jorge A, Simões, Cláudia M O, Caro, Miguel S B, Schenkel, Eloir P
Format:	Journal Article
Language:	English
Published:	Germany 01-09-2011
Subjects:	Brazil Cell Line, Tumor Cell Survival Chromatography, High Pressure Liquid Cucurbitaceae - chemistry Cucurbitacins - chemistry Cucurbitacins - isolation & purification Cucurbitacins - pharmacology Humans Medicine, Traditional Molecular Structure Plant Extracts - chemistry Plant Roots - chemistry Plants, Medicinal Spectrometry, Mass, Electrospray Ionization Brazil
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Summary:	Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (1- 2) and four known (3- 6) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity.
ISSN:	1439-0221
DOI:	10.1055/s-0030-1270962