Defective entry of herpes simplex virus types 1 and 2 into porcine cells and lack of infection in infant pigs indicate species tropism

We have determined if a defect at entry of the human pathogen herpes simplex virus type 1 (HSV-1) into cultured porcine cells extends to HSV-2 and if the poor susceptibility of porcine cells for these viruses is indicative of in vivo species tropism. HSV-1 replicates poorly in swine testis (ST) and...

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Bibliographic Details
Published in:	Journal of general virology Vol. 76; no. 9; pp. 2375 - 2379
Main Authors:	Subramanian, G, LeBlac, R.A, Wardley, R.C, Fuller, A.O
Format:	Journal Article
Language:	English
Published:	England Soc General Microbiol 01-09-1995
Subjects:	Animals Animals, Newborn Antibodies, Viral - analysis Cell Line cell lines Cytopathogenic Effect, Viral DNA, Viral - analysis embryo (animal) experimental infection experimental infections herpes simplex virus herpes simplex virus 1 herpes simplex virus 2 Herpesvirus 1, Human - pathogenicity Herpesvirus 1, Human - physiology Herpesvirus 2, Human - pathogenicity Herpesvirus 2, Human - physiology Humans Lung - cytology Lung - virology lungs Male Membrane Fusion neonates pathogenicity Receptors, Virus - metabolism species differences Swine symptoms testes Testis - cytology Testis - virology
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