SinoNasal Microbiota Transfer to treat recalcitrant chronic rhinosinusitis: A case series

SinoNasal Microbiota Transfer to treat recalcitrant chronic rhinosinusitis: A case series

Key points SinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up to 180 days. The addition of antimicrobial photodynamic therapy worsened chronic rhinosinusitis. These promising SNMT results warrant furthe...

Full description

Saved in:
Bibliographic Details
Published in:International forum of allergy & rhinology Vol. 14; no. 8; pp. 1386 - 1390
Main Authors: Gill, Sandeep K., Hernaiz‐Leonardo, Juan C., Edens, Thaddeus J., Pascual, Athenea, Tang, Chris, Fan, Judy, Thamboo, Andrew, Mullings, Warren, Alsaleh, Saad, Alim, Bader M., Javer, Amin R., Manges, Amee R.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-08-2024
Subjects:
Adult
Aged
Chronic Disease
chronic rhinosinusitis
experimental therapy
Female
Humans
Male
microbiome
microbiome therapy
Microbiota
Middle Aged
mucus transplant
Paranasal Sinuses - microbiology
Photodynamic therapy
Rhinitis - microbiology
Rhinitis - therapy
Rhinosinusitis
sinusitis
Sinusitis - microbiology
Sinusitis - therapy
Treatment Outcome
chronic rhinosinusitis
sinusitis
experimental therapy
microbiome
mucus transplant
microbiome therapy
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Key points SinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up to 180 days. The addition of antimicrobial photodynamic therapy worsened chronic rhinosinusitis. These promising SNMT results warrant further study of safety and efficacy.
AbstractList Key points SinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up to 180 days. The addition of antimicrobial photodynamic therapy worsened chronic rhinosinusitis. These promising SNMT results warrant further study of safety and efficacy.
Key pointsSinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up to 180 days.The addition of antimicrobial photodynamic therapy worsened chronic rhinosinusitis.These promising SNMT results warrant further study of safety and efficacy.
SinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up to 180 days. The addition of antimicrobial photodynamic therapy worsened chronic rhinosinusitis. These promising SNMT results warrant further study of safety and efficacy.KEY POINTSSinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up to 180 days. The addition of antimicrobial photodynamic therapy worsened chronic rhinosinusitis. These promising SNMT results warrant further study of safety and efficacy.
SinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up to 180 days. The addition of antimicrobial photodynamic therapy worsened chronic rhinosinusitis. These promising SNMT results warrant further study of safety and efficacy.
Author Tang, Chris
Edens, Thaddeus J.
Alim, Bader M.
Javer, Amin R.
Manges, Amee R.
Pascual, Athenea
Fan, Judy
Thamboo, Andrew
Mullings, Warren
Alsaleh, Saad
Gill, Sandeep K.
Hernaiz‐Leonardo, Juan C.
Author_xml – sequence: 1
  givenname: Sandeep K.
  surname: Gill
  fullname: Gill, Sandeep K.
  organization: University of British Columbia
– sequence: 2
  givenname: Juan C.
  orcidid: 0000-0002-3013-2683
  surname: Hernaiz‐Leonardo
  fullname: Hernaiz‐Leonardo, Juan C.
  organization: Department of Surgery, University of British Columbia
– sequence: 3
  givenname: Thaddeus J.
  surname: Edens
  fullname: Edens, Thaddeus J.
  organization: West Vancouver
– sequence: 4
  givenname: Athenea
  surname: Pascual
  fullname: Pascual, Athenea
  organization: Department of Surgery, University of British Columbia
– sequence: 5
  givenname: Chris
  surname: Tang
  fullname: Tang, Chris
  organization: University of British Columbia
– sequence: 6
  givenname: Judy
  surname: Fan
  fullname: Fan, Judy
  organization: Department of Surgery, University of British Columbia
– sequence: 7
  givenname: Andrew
  surname: Thamboo
  fullname: Thamboo, Andrew
  organization: Department of Surgery, University of British Columbia
– sequence: 8
  givenname: Warren
  surname: Mullings
  fullname: Mullings, Warren
  organization: University Hospital of the West Indies
– sequence: 9
  givenname: Saad
  surname: Alsaleh
  fullname: Alsaleh, Saad
  organization: King Saud University
– sequence: 10
  givenname: Bader M.
  orcidid: 0000-0002-6390-3405
  surname: Alim
  fullname: Alim, Bader M.
  organization: National Guard Health Affairs
– sequence: 11
  givenname: Amin R.
  orcidid: 0000-0001-9427-1853
  surname: Javer
  fullname: Javer, Amin R.
  email: sinusdoc@me.com
  organization: Department of Surgery, University of British Columbia
– sequence: 12
  givenname: Amee R.
  surname: Manges
  fullname: Manges, Amee R.
  email: amee.manges@ubc.ca
  organization: British Columbia Centre for Disease Control
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38616557$$D View this record in MEDLINE/PubMed
BookMark eNp10E1LwzAYB_AgiptzB7-ABLzoYVte28zbGL7BVNB58FTS7CnL6JqZtMi-vdHOHQRzSSC__MnzP0GHlasAoTNKhpQQNtKlHzLOJTtAXUYEGyRjJQ735zTpoH4IKxKXpFLS9Bh1uEpoImXaRe-vtnJPOugSP1rjXW5drfHc6yoU4HHtcO1B19iD0aWxdbyosVl6V1mD_TI-DrZqgq1tuMYTbHQAHMBbCKfoqNBlgP5u76G325v59H4we757mE5mA8OFYoOFVCbVRc4SSJQSVCpFucnpmKYAqii4ELzgcT65yLnOiaaF0EKQSJQ2xvAeumxzN959NBDqbG2DgbLUFbgmZJzwMeMyDh_pxR-6co2v4u-iUomiilMW1VWrYh0heCiyjbdr7bcZJdl35VmsPPupPNrzXWKTr2Gxl78FRzBqwactYft_UjaZvbSRX0jUi-g
Cites_doi 10.1002/lary.25180
10.1093/ofid/ofaa114
10.1177/1945892419876394
10.1093/CID/CIX684
10.1186/s40463‐018‐0287‐6
ContentType Journal Article
Copyright 2024 The Authors. published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.
2024 The Authors. International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.
2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: 2024 The Authors. published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.
– notice: 2024 The Authors. International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.
– notice: 2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID 24P
WIN
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
K9.
7X8
DOI 10.1002/alr.23352
DatabaseName Wiley Open Access
Wiley Online Library Journals
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Health & Medical Complete (Alumni)
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest Health & Medical Complete (Alumni)
MEDLINE - Academic
DatabaseTitleList
ProQuest Health & Medical Complete (Alumni)
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: ECM
  name: MEDLINE
  url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2042-6984
EndPage 1390
ExternalDocumentID 10_1002_alr_23352
38616557
ALR23352
Genre article
Journal Article
Case Reports
GrantInformation_xml – fundername: Canadian Institutes of Health Research (CIHR) Project Grant
  funderid: PJT‐183766
– fundername: CIHR Doctoral Award
  funderid: FRN‐171447
– fundername: Canadian Institutes of Health Research
  funderid: CIHR; FRN‐171447; PJT‐183766
– fundername: CIHR
  grantid: FRN-171447
– fundername: Canadian Institutes of Health Research (CIHR) Project Grant
  grantid: PJT-183766
– fundername: CIHR
  grantid: PJT-183766
– fundername: CIHR
  grantid: CIHR
– fundername: CIHR Doctoral Award
  grantid: FRN-171447
GroupedDBID ---
05W
0R~
1OC
24P
31~
33P
4.4
50Y
52T
52V
53G
7PT
8-0
8-1
A00
AAESR
AAHHS
AANLZ
AASGY
AAXRX
AAZKR
ABCUV
ABDBF
ABJNI
ABQWH
ABXGK
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFS
ACGOF
ACMXC
ACPOU
ACXBN
ACXQS
ADBBV
ADBTR
ADEOM
ADKYN
ADMGS
ADOZA
ADXAS
ADZMN
ADZOD
AEEZP
AEIGN
AENEX
AEQDE
AEUYR
AFBPY
AFFPM
AFGKR
AFPWT
AFZJQ
AHBTC
AHMBA
AIACR
AITYG
AIURR
AIWBW
AJBDE
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMYDB
ASPBG
AVWKF
AZFZN
AZVAB
BDRZF
BFHJK
BMXJE
BRXPI
D-A
DCZOG
DRFUL
DRMAN
DRSTM
EBD
EBS
EJD
FEDTE
FUBAC
G-S
GODZA
HGLYW
HVGLF
HZ~
KBYEO
LATKE
LEEKS
LITHE
LOXES
LP6
LP7
LUTES
LYRES
MEWTI
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
MY.
MY~
O9-
OVD
P2W
P4E
PQQKQ
ROL
RX1
SUPJJ
TEORI
WBKPD
WIN
WOHZO
WXSBR
WYJ
ZZTAW
CGR
CUY
CVF
ECM
EIF
NPM
AAMNL
AAYXX
CITATION
K9.
7X8
ID FETCH-LOGICAL-c3482-d58c7afb26e6884158813cb1917ee8ff3443f33355db3ab0a1f4a440cb18accc3
IEDL.DBID 33P
ISSN 2042-6976
2042-6984
IngestDate Tue Nov 19 07:17:57 EST 2024
Thu Oct 10 22:34:26 EDT 2024
Fri Nov 22 02:35:54 EST 2024
Sat Nov 02 12:29:50 EDT 2024
Sat Aug 24 00:55:46 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Keywords chronic rhinosinusitis
sinusitis
experimental therapy
microbiome
mucus transplant
microbiome therapy
Language English
License Attribution-NonCommercial-NoDerivs
2024 The Authors. International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3482-d58c7afb26e6884158813cb1917ee8ff3443f33355db3ab0a1f4a440cb18accc3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Report-3
ObjectType-Case Study-4
ORCID 0000-0002-3013-2683
0000-0001-9427-1853
0000-0002-6390-3405
OpenAccessLink https://onlinelibrary.wiley.com/doi/abs/10.1002%2Falr.23352
PMID 38616557
PQID 3086818312
PQPubID 996378
PageCount 5
ParticipantIDs proquest_miscellaneous_3039235051
proquest_journals_3086818312
crossref_primary_10_1002_alr_23352
pubmed_primary_38616557
wiley_primary_10_1002_alr_23352_ALR23352
PublicationCentury 2000
PublicationDate August 2024
PublicationDateYYYYMMDD 2024-08-01
PublicationDate_xml – month: 08
  year: 2024
  text: August 2024
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Hoboken
PublicationTitle International forum of allergy & rhinology
PublicationTitleAlternate Int Forum Allergy Rhinol
PublicationYear 2024
Publisher Wiley Subscription Services, Inc
Publisher_xml – name: Wiley Subscription Services, Inc
References 2020; 7
2018; 66
2015; 125
2020; 34
2018; 47
e_1_2_7_6_1
e_1_2_7_5_1
e_1_2_7_4_1
e_1_2_7_3_1
e_1_2_7_2_1
References_xml – volume: 7
  issue: 5
  year: 2020
  article-title: The efficacy and safety of fecal microbiota transplant for recurrent infection: current understanding and gap analysis
  publication-title: Open Forum Infect Dis
– volume: 66
  start-page: 134
  issue: 1
  year: 2018
  end-page: 135
  article-title: Early antibiotic use after fecal microbiota transplantation increases risk of treatment failure
  publication-title: Clin Infect Dis
– volume: 47
  start-page: 40
  issue: 1
  year: 2018
  article-title: The impact of chronic airway disease on symptom severity and global suffering in Canadian rhinosinusitis patients
  publication-title: J Otolaryngol Head Neck Surg
– volume: 34
  start-page: 127
  issue: 1
  year: 2020
  end-page: 133
  article-title: Treatment of recalcitrant maxillary sinusitis with endoscopic modified medial maxillectomy: a systematic review of safety and efficacy
  publication-title: Am J Rhinol Allergy
– volume: 125
  start-page: 1547
  issue: 7
  year: 2015
  end-page: 1556
  article-title: Cost of adult chronic rhinosinusitis: a systematic review
  publication-title: Laryngoscope
– ident: e_1_2_7_2_1
  doi: 10.1002/lary.25180
– ident: e_1_2_7_4_1
  doi: 10.1093/ofid/ofaa114
– ident: e_1_2_7_3_1
  doi: 10.1177/1945892419876394
– ident: e_1_2_7_5_1
  doi: 10.1093/CID/CIX684
– ident: e_1_2_7_6_1
  doi: 10.1186/s40463‐018‐0287‐6
SSID ssj0000515517
Score 2.372096
Snippet Key points SinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up...
SinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up to 180...
Key pointsSinoNasal Microbiota Transfer (SNMT) was safe with immediate benefit in all recipients, with sustained improvement in two of three recipients for up...
SourceID proquest
crossref
pubmed
wiley
SourceType Aggregation Database
Index Database
Publisher
StartPage 1386
SubjectTerms Adult
Aged
Chronic Disease
chronic rhinosinusitis
experimental therapy
Female
Humans
Male
microbiome
microbiome therapy
Microbiota
Middle Aged
mucus transplant
Paranasal Sinuses - microbiology
Photodynamic therapy
Rhinitis - microbiology
Rhinitis - therapy
Rhinosinusitis
sinusitis
Sinusitis - microbiology
Sinusitis - therapy
Treatment Outcome
Title SinoNasal Microbiota Transfer to treat recalcitrant chronic rhinosinusitis: A case series
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Falr.23352
https://www.ncbi.nlm.nih.gov/pubmed/38616557
https://www.proquest.com/docview/3086818312
https://www.proquest.com/docview/3039235051
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwFA66B_HF-2U6JYoPvtS1TS-pPg3d2IMb4hT0qZymKRZGJ2v3_z1J1soQQfAtkBMSkpx8Xy7nCyFXLPSVLFpqcWFnlhcJ34p8kJbjAfMixE-Wqtjh4SQcv_GHvpLJuatjYYw-RHPgpjxDr9fKwSEpu9-ioTCd37gqYgjXX9wl6PAN9tScr5i_S1S0tKsiUAKE3VpYyHa7TeFVOPrBMVcpq8acwfa_WrtDtpZUk_bM3Ngla7LYIxuj5WX6Pnmf5MVsDCXajHKjx1QB1eCVyTmtZlS_Qqe4JsJU5BVmVFQYMV06_8DCZV4s1Juv8pb2qEA8pGpCy_KAvA76L_dDa_nTgiWUuI2V-lyEkCVuIAPOEdM5d5hI1F5OSp5lzPNYxrD5fpowSGxwMg88z0YTDkIIdkhaxayQx4RKBkhxAHkNkpMIInBEkAVcKh02noROm1zWHR5_GkGN2EgnuzF2Uqw7qU069VDES58qY4a7L6QXzMHsiyYbvUFdcUAhZwtlg3yPIavDeo7MEDa1MB44ge-HbXKtR-r36uPe47NOnPzd9JRsush3zNvADmlV84U8I-tlujjXE_MLLcriaA
link.rule.ids 315,782,786,1408,27933,27934,46064,46488
linkProvider Wiley-Blackwell
linkToHtml http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ZS8QwEB48QH3xPtYzig--VLdN2qbiy-LBiruLeIA-lTRNcUG6su3-f2ea3YqIIPhWyISEZCbf1yTzBeCYhz7JoqWO1M3MEZH2nchXxnGF4iJC_OQp5Q63H8Pei7y6Jpmci0kujNWHqDfcKDKq9ZoCnDakz75UQ9X78NSjlKFpmBUBOiIlcPD7eofFvl5C-dIe5aAECLwTaaGmd1bX_g5IP1jmd9Jaoc7N0v_6uwyLY7bJWtY9VmDK5Ksw1x2fp6_B62M_H_RUgTbdvpVkKhWr8CszQ1YOWHURneGyqN51v8SCkmmrp8uGb1i56OcjuvZVnLMW0wiJjHzaFOvwfHP9dNl2xo8tOJr0bZzUlzpUWeIFJpASYV1Kl-uEfueMkVnGheAZx-77acJV0lRuJpQQTTSRSmvNN2AmH-RmC5jhClmOQmqD_CRSkXJ1kAXSkBSbTEK3AUeTEY8_rKZGbNWTvRgHKa4GqQG7k7mIx2FVxBx_wJBhcBeLD-tiDAg65VC5GYzIBikfR2KH7WzaOaxb4TJwA98PG3BSTdXvzcetzkP1sf130wOYbz91O3Hntne3Awse0h97VXAXZsrhyOzBdJGO9isv_QSH9eaQ
linkToPdf http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwFD7ohOGL98t0ahQffKlbm7RN9WmoQ9GN4QX0qaRpggPpZO3-vyfNVhkiCL4FckJCkpPvy-V8ATiloW9k0VKHy7Z2WCR9J_KFclwmKIsQP2lqYodvn8L-K7--MTI5l7NYGKsPUR24Gc8o12vj4J-pbn2LhoqP8blnIoYWYYkhDTfC-ZQOqgMW-3mJCZf2TAhKgLg7UxZqe62q9Dwe_SCZ85y1BJ3u6r-auwYrU65JOnZyrMOCyjag3pvepm_C29MwG_VFjja9oRVkKgQp0UurMSlGpHyGTnBRFB9yWGBGQaRV0yXjdyycD7OJefSVX5AOkQiIxMxolW_BS_fm-erWmX614EijbuOkPpeh0IkXqIBzBHXOXSoTs5lTimtNGaOaYvP9NKEiaQtXM8FYG024kFLSbahlo0ztAlFUIMcRSGyQnUQiEq4MdMCVEWLjSeg24GTW4fGnVdSIrXayF2MnxWUnNaA5G4p46lR5THH7hfyCuph9XGWjO5g7DpGp0cTYIOGjSOuwnh07hFUtlAdu4PthA87Kkfq9-rjz8Fgm9v5uegT1wXU3frjr3-_Dsofcx74TbEKtGE_UASzm6eSwnKNfzFflNg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=SinoNasal+Microbiota+Transfer+to+treat+recalcitrant+chronic+rhinosinusitis%3A+A+case+series&rft.jtitle=International+forum+of+allergy+%26+rhinology&rft.au=Gill%2C+Sandeep+K.&rft.au=Hernaiz%E2%80%90Leonardo%2C+Juan+C.&rft.au=Edens%2C+Thaddeus+J.&rft.au=Pascual%2C+Athenea&rft.date=2024-08-01&rft.issn=2042-6976&rft.eissn=2042-6984&rft.volume=14&rft.issue=8&rft.spage=1386&rft.epage=1390&rft_id=info:doi/10.1002%2Falr.23352&rft.externalDBID=10.1002%252Falr.23352&rft.externalDocID=ALR23352
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2042-6976&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2042-6976&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2042-6976&client=summon