Serum lipid levels and in-hospital mortality in patients with intracerebral hemorrhage

• Published in: Neurology Vol. 65; no. 8; pp. 1198 - 1202
• Main Authors: ROQUER, J, RODRIGUEZ CAMPELLO, A, GOMIS, M, OIS, A, MUNTEIS, E, BÖHM, P
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 25-10-2005
• Subjects: Biological and medical sciences; Brain - blood supply; Brain - metabolism; Brain - physiopathology; Cerebral Arteries - metabolism; Cerebral Arteries - physiopathology; Cerebral Hemorrhage - blood; Cerebral Hemorrhage - mortality; Cholesterol - blood; Cholesterol - deficiency; Comorbidity - trends; Hospitalization - statistics & numerical data; Medical sciences; Mortality; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; Predictive Value of Tests; Risk Factors; Triglycerides - blood; Triglycerides - deficiency; Vascular diseases and vascular malformations of the nervous system; Vascular disease; Human; Nervous system diseases; Cerebral hemorrhage; Mortality; Central nervous system disease; Cardiovascular disease; Lipids; Hospital; Cerebrovascular disease; Cerebral disorder
• ISSN: 0028-3878; 1526-632X
• DOI: 10.1212/01.wnl.0000180968.26242.4a

To test the hypothesis that low serum cholesterol and low serum triglyceride levels at admission are related to an increase of in-hospital mortality in patients with first-ever supratentorial spontaneous intracerebral hemorrhage (ICH).
The authors obtained the serum cholesterol and triglyceride levels during the first 48 hours after first-ever ICH in 184 patients. They analyzed the impact of serum cholesterol and triglyceride concentrations on the in-hospital mortality after adjustment for possible confounding variables according to the results of the univariate analysis (age, hemorrhage volume, intraventricular extension, glycemia, serum albumin, and Glasgow Coma Scale score at admission) using the Cox proportional hazards model. They also analyzed the survival curves according to the cholesterol and triglyceride quartiles.
Low serum cholesterol (p = 0.002; hazard ratio [HR] 0.988 [95% CI 0.979 to 0.997] mg/dL) and low serum triglyceride (p = 0.011; HR 0.986 [95% CI 0.976 to 0.997] mg/dL) concentrations were independently associated with increased in-hospital mortality after ICH. Analyzed by quartiles, the HR of in-hospital mortality was 3.136 (95% CI 0.833 to 11.087) for patients in the lowest cholesterol quartile (< 166 mg/dL) and 3.484 (95% CI 1.088 to 11.155) for patients in the lowest triglyceride quartile (< 74 mg/dL).
Low serum cholesterol and triglyceride levels obtained during the first hours after intracerebral hemorrhage (ICH) are strong independent predictors of in-hospital mortality in patients with spontaneous supratentorial ICH.