Thymopoiesis and T cell development in common gamma chain-deficient dogs

Our laboratory has identified an X-linked severe combined immunodeficiency (XSCID) in dogs that is the result of mutations in the common gamma chain (gammac) subunit of the interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21 receptors. Canine XSCID, unlike genetically engineered gammac-deficien...

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Bibliographic Details
Published in:	Immunologic research Vol. 27; no. 2-3; pp. 235 - 246
Main Authors:	Felsburg, Peter J, Hartnett, Brian J, Gouthro, Terry A, Henthorn, Paula S
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-01-2003
Subjects:	Animals Cell Differentiation - immunology Disease Models, Animal Dogs Gene therapy Humans Immunology interleukin receptors Mutation Receptors, Interleukin - genetics Receptors, Interleukin - immunology Severe Combined Immunodeficiency - etiology Severe Combined Immunodeficiency - immunology Stem cells T cell receptors T-Lymphocytes - immunology thymopoiesis Thymus Gland - growth & development Thymus Gland - immunology
Online Access:	Get full text
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