Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease

• Published in: Acta neuropathologica Vol. 100; no. 3; pp. 270 - 274
• Main Authors: SAKURAI, A, OKAMOTO, K, FUJITA, Y, NAKAZATO, Y, WAKABAYASHI, K, TAKAHASHI, H, GONATAS, N. K
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01-09-2000; Springer Nature B.V
• Subjects: Aged; Biological and medical sciences; Bovine spongiform encephalopathy; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Creutzfeldt-Jakob disease; Creutzfeldt-Jakob Syndrome - metabolism; Creutzfeldt-Jakob Syndrome - pathology; Creutzfeldt-Jakob Syndrome - physiopathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Glycoproteins; Golgi apparatus; Golgi Apparatus - metabolism; Golgi Apparatus - pathology; Humans; Male; Medical sciences; Membrane Glycoproteins - metabolism; Membrane Proteins; Middle Aged; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Nerve Degeneration - physiopathology; Neurology; Neurons - metabolism; Neurons - pathology; Receptors, Cell Surface; Receptors, Fibroblast Growth Factor; Sialoglycoproteins - metabolism; Human; Immunohistochemistry; Nervous system diseases; Exploration; Basal ganglion; Cerebral disorder; Golgi apparatus; Infection; Pathology; Neuron; Central nervous system disease; Degenerative disease; Degeneration; Prion; Creutzfeldt Jakob disease
• ISSN: 0001-6322; 1432-0533
• DOI: 10.1007/s004010000182

We investigated immunohistologically the Golgi apparatus (GA) and the trans-Golgi network (TGN) of the cortical ballooned neurons (BNs) in two patients with corticobasal degeneration and in five with Creutzfeldt-Jakob disease. We observed that the BNs showed fragmentation of the GA and the TGN, accompanied by a reduction in the number of fragmented Golgi elements and by a unique perinuclear distribution. This is the first report of the abnormalities of GA in cortical BNs. These findings suggests that the GA and the TGN may play some roles in the BN formation.