Synthesis, spectroscopic characterization, electrochemistry and biological evaluation of some binuclear transition metal complexes of bicompartmental ONO donor ligands containing benzo[b]thiophene moiety

• Published in: Journal of molecular structure Vol. 1059; pp. 280 - 293
• Main Authors: Mahendra Raj, K., Vivekanand, B., Nagesh, G.Y., Mruthyunjayaswamy, B.H.M.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 05-02-2014
• Subjects: Antiinfectives and antibacterials; Benzo[b]thiophene; Binuclear complexes; Chelation; Electrochemistry; Electrophoresis; ESR; Ligands; Molecular structure; Spectroscopic analysis; Spectroscopy; TG–DTA; Unit cell; Binuclear complexes; Electrochemistry; TG–DTA; Benzo[b]thiophene; ESR
• ISSN: 0022-2860; 1872-8014
• DOI: 10.1016/j.molstruc.2013.12.010

•Synthesis, characterization of bicompartmental ligands and their metal complexes.•ESR spectral data proved the binuclear nature of the metal complexes.•Cu(II) complexes showed the redox property.•The synthesized complexes shows promising antimicrobial activities compared to ligands.•The complexes have good ability to cleave the super coiled DNA.
A series of new binucleating Cu(II), Co(II), Ni(II) and Zn(II) complexes of bicompartmental ligands with ONO donor were synthesized. The ligands were obtained by the condensation of 3-chloro-6-substituted benzo[b]thiophene-2-carbohydrazides and 4,6-diacetylresorcinol. The synthesized ligands and their complexes were characterized by elemental analysis and various spectroscopic techniques. Elemental analysis, IR, 1H NMR, ESI-mass, UV–Visible, TG–DTA, magnetic measurements, molar conductance and powder-XRD data has been used to elucidate their structures. The bonding sites are the oxygen atom of amide carbonyl, azomethine nitrogen and phenolic oxygen for ligands 1 and 2. The binuclear nature of the complexes was confirmed by ESR spectral data. TG–DTA studies for some complexes showed the presence of coordinated water molecules and the final product is the metal oxide. All the complexes were investigated for their electrochemical activity, only the Cu(II) complexes showed the redox property. Cu(II) complexes were square planar, whereas Co(II), Ni(II) and Zn(II) complexes were octahedral. Powder-XRD pattern have been studied in order to test the degree of crystallinity of the complexes and unit cell calculations were made. In order to evaluate the effect of antimicrobial activity of metal ions upon chelation, both the ligands and their metal complexes were screened for their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The results showed that the metal complexes were found to be more active than free ligands. The DNA cleaving capacities of all the complexes were analyzed by agarose gel electrophoresis method against supercoiled plasmid DNA. Among the compounds tested for antioxidant capacity, ligand 1 displayed excellent activity than its metal complexes.