Heart⁻Lung⁻Muscle Anti-SAE Syndrome: An Atypical Severe Combination

Heart⁻Lung⁻Muscle Anti-SAE Syndrome: An Atypical Severe Combination

A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated...

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Bibliographic Details
Published in:Journal of clinical medicine Vol. 8; no. 1; p. 20
Main Authors: Zamora, Elisabet, Seder-Colomina, Elena, Holgado, Susana, Quirant-Sanchez, Bibiana, Mate, José Luis, Martínez-Cáceres, Eva M, Casafont, Ivette, Bayés-Genís, Antoni
Format: Journal Article
Language:English
Published: Switzerland MDPI 23-12-2018
Subjects:
Case Report
idiopathic inflammatory myopathy
anti-SAE antibody
myocarditis
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Summary:A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated a diagnosis of myocarditis, confirmed with cardiac magnetic resonance imaging and endomyocardial biopsy. A comprehensive immune work-up revealed anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibody, a novel myositis-specific antibody, previously described mainly with overt cutaneous dermatomyositis and late skeletal muscle manifestations. Here, heart⁻lung⁻muscle involvement combined with anti-SAE antibodies was a severe combination.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm8010020