Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome

• Published in: Neurology Vol. 63; no. 7; pp. 1289 - 1292
• Main Authors: TAKEOKA, M, RIVIELLO, J. J, DUFFY, F. H, KIM, F, KENNEDY, D. N, MAKRIS, N, CAVINESS, V. S, HOLMES, G. L
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 12-10-2004
• Subjects: Auditory Cortex - pathology; Biological and medical sciences; Case-Control Studies; Cerebral Cortex - pathology; Child; Child, Preschool; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Landau-Kleffner Syndrome - pathology; Magnetic Resonance Imaging; Male; Malformations of the nervous system; Medical sciences; Neocortex - pathology; Nervous system (semeiology, syndromes); Neurology; Organ Size; Temporal Lobe - pathology; Landau Kleffner syndrome; Nervous system diseases
• ISSN: 0028-3878; 1526-632X
• DOI: 10.1212/01.WNL.0000140703.63270.9D

No specific anatomic abnormalities have been detected in typical Landau-Kleffner syndrome (LKS), an acquired epileptic aphasia with language regression in children. In four children with typical LKS without obvious anatomic abnormalities, the authors performed MRI volumetric analysis of various neocortical regions and subcortical substructures. Volume reduction was detected in bilateral superior temporal areas (26 to 51%), specifically in planum temporale (25 to 63%) and superior temporal gyrus (25 to 57%), where receptive language is localized.