Identification in in vivo acetylation pathway for N-dealkylated metabolites of doxylamine in humans

1. Metabolites of doxylamine in human urine were separated by g.l.c. and h.p.l.c. and tentatively identified by their mass spectrometric behaviour. 2. N-Desmethyldoxylamine, N,N-didesmethyldoxylamine and their N-acetyl conjugates were identified. This is believed to be the first report of acetylatio...

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Bibliographic Details
Published in:	Xenobiotica Vol. 17; no. 8; p. 993
Main Authors:	Ganes, D A, Midha, K K
Format:	Journal Article
Language:	English
Published:	England 1987
Subjects:	Acetylation Chromatography, Gas Chromatography, High Pressure Liquid Dealkylation Doxylamine - metabolism Doxylamine - urine Humans Male Mass Spectrometry Pyridines - metabolism
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Summary:	1. Metabolites of doxylamine in human urine were separated by g.l.c. and h.p.l.c. and tentatively identified by their mass spectrometric behaviour. 2. N-Desmethyldoxylamine, N,N-didesmethyldoxylamine and their N-acetyl conjugates were identified. This is believed to be the first report of acetylation in vivo of primary and secondary aliphatic amines in man.
ISSN:	0049-8254
DOI:	10.3109/00498258709044198