Depletion of Kupffer cell function by gadolinium chloride attenuates thioacetamide-induced hepatotoxicity: Expression of metallothionein and HSP70

Kupffer cell function plays an important role in drug-induced liver injury. Thus, gadolinium chloride (GD), by selectively inactivating Kupffer cells, can alleviate drug-induced hepatotoxicity. The effect of GD was studied in reference to metallothionein and heat shock proteins expression in an in v...

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Bibliographic Details
Published in:	Biochemical pharmacology Vol. 66; no. 6; pp. 917 - 926
Main Authors:	Andrés, David, Sánchez-Reus, Isabel, Bautista, Mirandeli, Cascales, Marı́a
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 15-09-2003 Elsevier Science
Subjects:	Animals Anti-Inflammatory Agents - pharmacology Biological and medical sciences Biotransformation Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Drug Interactions Gadolinium - pharmacology Gadolinium - therapeutic use Gadolinium chloride Gene Expression - drug effects HSP70 HSP70 Heat-Shock Proteins - biosynthesis Kupffer cells Kupffer Cells - drug effects Kupffer Cells - physiology Male Medical sciences Metallothionein Metallothionein - biosynthesis Microsomes, Liver - metabolism Mixed Function Oxygenases - metabolism NADP - metabolism Oxidative Stress - drug effects Pharmacology. Drug treatments Rats Rats, Wistar Thioacetamide - antagonists & inhibitors Thioacetamide - toxicity Thioacetamide hepatotoxicity Thioacetamide hepatotoxicity HSP70 Gadolinium chloride Metallothionein Kupffer cells Depletion Toxicity Pharmacology
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