Primary breast lymphoma : The role of mastectomy and the importance of lymph node status

• Published in: Annals of surgery Vol. 245; no. 5; pp. 784 - 789
• Main Authors: JENNINGS, William C, BAKER, Randal S, MURRAY, Sunshine S, HOWARD, C. Anthony, PARKER, Donald E, PEABODY, Linda F, VICE, Heather M, SHEEHAN, William W, BROUGHAN, Thomas A
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01-05-2007
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Axilla; Biological and medical sciences; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Databases, Factual; Female; Follow-Up Studies; General aspects; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymph Nodes - pathology; Lymphoma - mortality; Lymphoma - pathology; Lymphoma - therapy; Mastectomy; Medical sciences; Middle Aged; Original; Retrospective Studies; Survival Rate; Treatment Outcome; Medicine; Treatment; Lymph node; Lymphoproliferative syndrome; Surgery; Primary; Mastectomy; Breast; Malignant hemopathy; Mammary gland; Lymphoid neoplasm; Lymphoma
• DOI: 10.1097/01.sla.0000254418.90192.59
• EISSN: 1528-1140
• ISSN: 0003-4932

To construct and analyze a database comprised of all reported cases of primary breast lymphoma (PBL) that include treatment and follow-up information published during the last 3 decades.
PBL accounts for 0.4% of breast malignancies and 2% of extranodal lymphomas. Surgical therapy has varied from biopsy to radical mastectomy. Chemotherapy and radiation therapy have been used as adjuvant or primary therapy. A standard consensus treatment of PBL is not available.
We reviewed all published PBL reports from June 1972 to March 2005. A database was compiled by abstracting individual patient information, limiting our study to those reports that contained specific treatment and outcome data. Patient demographics such as survival, recurrence, and time to follow-up were recorded, in addition to surgical, radiation, and/or chemotherapy treatment(s).
We found 465 acceptable patients reported in 92 publications. Age range was 17 to 95 years (mean, 54 years). Mean tumor size was 3.5 cm. Diffuse large cell (B) lymphoma was the most common histologic diagnosis (53%). Disease-free survival was 44.5% overall. Follow-up ranged from one to 288 months (mean, 48 months). Treatment by mastectomy offered no survival benefit or protection from recurrence. Treatment that included radiation therapy in stage I patients (node negative) showed benefit in both survival and recurrence rates. Treatment that included chemotherapy in stage II patients (node positive) showed benefit in both survival and recurrence rates. Histologic tumor grade predicted survival.
Mastectomy offers no benefit in the treatment of PBL. Nodal status predicts outcome and guides optimal use of radiation and chemotherapy.