Quorum sensing regulation in Pseudomonas

• Published in: Russian journal of genetics Vol. 46; no. 2; pp. 129 - 137
• Main Author: Veselova, M. A
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : SP MAIK Nauka/Interperiodica 01-02-2010; SP MAIK Nauka/Interperiodica
• Subjects: Animal Genetics and Genomics; Biomedical and Life Sciences; Biomedicine; Human Genetics; Microbial Genetics and Genomics; Pseudomonas; Reviews and Theoretical Articles; Acyl Homoserine Lactone; Phenazine; Quorum Sense; Quorum Sense System; Homoserine Lactone
• ISSN: 1022-7954; 1608-3369
• DOI: 10.1134/S1022795410020018

Expression of many bacterial genes is regulated in a cell density-dependent manner via small signal molecules known as autoinducers; this type of regulation is termed quorum sensing (QS). The QS systems that employ N-acyl-homoserine lactones (HSLs) are best un derstood in Gram-negative bacteria. QS regulates expression of various genes, including the genes responsible for the production of virulence factors, synthesis of exoenzymes and antibiotics, antagonistic properties of bacteria, etc. The QS systems of the genus Pseudomonas are linked to other global regulatory networks of the cell, and their functions are controlled by numerous additional regulatory factors. Such regulators and the QS systems together form an intricate multifactorial cascade regulatory network. The review considers the QS systems of several Pseudomonas species, their interaction with other regulatory systems, and their roles in the regulation of cell processes.